Cell Biology Recombinant Proteins

Human CD44 Recombinant Protein (RPES5202)

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SKU:
RPES5202
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology

Description

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Human CD44 Recombinant Protein

CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands; such as osteopontin; collagens; and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore; an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium; stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.

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