Immune Checkpoint Recombinant Proteins

Human CD40 Recombinant Protein (mFc-His Tag) (HDPT0015)

(No reviews yet) Write a Review

SKU:: HDPT0015
UPC:
MPN:
Product Type:: Recombinant Protein
Species:: Human
Research Area:: Immune Checkpoint

Description
0 Reviews

Description

Human CD40 Recombinant Protein (mFc-His Tag)

Description:	This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Product name:	Human CD40 Recombinant Protein (mFc-His Tag)
Synonyms:	CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Type:	protein
Size:	50 µg
Name:	CD40
Origin:	Human
Source:	HEK293
Protein Type:	Recombinant
Application:	ELISA
Purity:	> 95%
Purification:	affinity purification
Format:	Lyophilized
Conjugate:	C-Mouse Fc and 6×His tag
Storage:	Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:	Research use only
Buffer:	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:	Reconstitute with deionized water
Sequence:	CD40（Glu21-Arg193）+mFc（Pro99-Lys330）+6×His
Gene ID:	958
Uniprot:	P25942
Molecular Weight:	68 kDa