Immunology Recombinant Proteins
Human CD4/LEU3 Recombinant Protein (RPES4520)
- SKU:
- RPES4520
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human CD4/LEU3 Recombinant Protein
CD4 is an approximately 55?kDa type?I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T?lymphocytes. It is a standard phenotype marker for the identification of T?cell populations. Mature human CD4 consists of a 371?amino acid extracellular region containing four immunoglobulin-like domains; a 22?aa transmembrane segment; and a 40?aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T?cells during their development in the thymus. CD4 binds directly to MHC class?II molecules on antigen presenting cells (10). This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and; in human; as a co-receptor for the gp120 surface glycoprotein of HIV-1.
| Product Name: | Human CD4/LEU3 Recombinant Protein (RPES4520) |
| Product Code: | RPES4520 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | T-cell surface glycoprotein CD4,T-cell surface antigen T4/Leu-3,CD4,Scd4,CD4mut |
| Accession: | P01730 |
| Sequence: | Lys26-Trp390 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human CD4 is produced by our Mammalian expression system and the target gene encoding Lys26-Trp390 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
| Mol Mass: | 67.6 kDa |
| AP Mol Mass: | 70-85 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS;1mM EDTA;PH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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