Human CD3E Polyclonal Antibody
- SKU:
- CAB24879
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Human CD3E Polyclonal Antibody |
| Product Code: | CAB24879 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | MOLT-4, Jurkat |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-126 of human CD3E(NP_000724.1). |
| Sequence: | DGNEE MGGIT QTPYK VSISG TTVIL TCPQY PGSEI LWQHN DKNIG GDEDD KNIGS DEDHL SLKEF SELEQ SGYYV CYPRG SKPED ANFYL YLRAR VCENC MEMD |
| Synonyms: | CD3E, IMD18, T3E, TCRE, CD3e molecule |
| Calculated MW: | 23kDa |
| Observed MW: | 23kDa |
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