](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/11123/15177/human-cd35-monoclonal-antibody-e11agel0257__48847__25016.1706269363.jpg?c=1?imbypass=on "Human CD35 Monoclonal Antibody [E11](AGEL0257)")
Description
system_update_altDatasheet
| Antibody Name: | Human CD35 Monoclonal Antibody |
| Antibody Code: | AGEL0257 |
| Size: | 100µg |
| Clone: | E11 |
| Synonyms: | Complement receptor type 1, CR1, C3b/C4b receptor, CD35, CR1, C3BR |
| Host Species: | Mouse |
| Species Reactivity: | Human |
| Applications: | FC, IHC, IP |
| Concentration: | 1mg/mL |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Applications: | FC, IHC, IP |
| Recommended Dilution: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | PBS with 0.05% Proclin300 |
| Storage: | Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Gene ID: | 1378 |
| Uniprot: | P17927 |
| Background: | CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation. |
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