Human CD35 Monoclonal Antibody [E11](AGEL0257)

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SKU:
AGEL0257
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
E11
Conjugation:
Unconjugated
Applications:
FC
Applications:
IHC
Applications:
IP

Description

system_update_altDatasheet
Antibody Name:Human CD35 Monoclonal Antibody
Antibody Code:AGEL0257
Size:100µg
Clone:E11
Synonyms:Complement receptor type 1, CR1, C3b/C4b receptor, CD35, CR1, C3BR
Host Species:Mouse
Species Reactivity:Human
Applications:FC, IHC, IP
Concentration:1mg/mL
Isotype:IgG1
Conjugation:Unconjugated
Applications:FC, IHC, IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300
Storage:Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Gene ID:1378
Uniprot:P17927
Background:CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.
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