Human CD31/PECAM1 Recombinant Protein (RPES2083)

Human CD31/PECAM1 Recombinant Protein

Platelet Endothelial Cell Adhesion Molecule (PECAM1, CD31),is a heavily glycosylated transmembrane protein belonging to theimmunoglobulin (Ig) superfamily of cell adhesion molecules. CD31 is composed of an extracellular domain (ECD) of 574 amino acids (aa) containing six Ig-likedomains, a transmembrane domain, and a 118 aacytoplasmic domain. CD31 is highly expressed on endothelial cells and at a lower level on platelets, granulocytes,macrophages, dendritic cells, T and B cells, and natural killer (NK) cells. It is involved in cell adhesion and is required for transepithelial migration of leukocytes (TEM). CD31 acts as a homophilic receptor through itsextracellular domain and is involved in downstream signaling via its cytoplasmic domain. This domain contains highly conserved ITIM motifs which, once tyrosinephosphorylated, recruit and activate the signaling molecules Src and SHP2. The resulting inhibition of TCR signaling increases the activation threshold ofT cells, thus reinforcing peripheral tolerance and preventing development of autoimmunity. CD31 additionally regulates immune responses by acting as a keyinhibitory receptor in dendritic cell development. CD31 is required for the transendothelial migration of leukocytes through intercellular junctions of vascular endothelial cells.