CD Antigens Recombinant Proteins

Human CD30 Recombinant Protein (RPPB5876)

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SKU:
RPPB5876
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P28908
Research Area:
CD Antigens

Description

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Product Name:Human CD30 Recombinant Protein
Product Code:RPPB5876
Size:10µg
Species:Human
Target:CD30
Synonyms:CD30, D1S166E, KI-1, Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, TNFRSF8.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CD30 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSFPQDRPF EDTCHGNPSH YYDKAVRRCC YRCPMGLFPT QQCPQRPTDC RKQCEPDYYL DEADRCTACV TCSRDDLVEK TPCAWNSSRV CECRPGMFCS TSAVNSCARC FFHSVCPAGM IVKFPGTAQK NTVCEPASPG VSPACASPEN CKEPSSGTIP QAKPTPVSPA TSSASTMPVR GGTRLAQEAA SKLTRAPDSP SSVGRPSSDP GLSPTQPCPE GSGDCRKQCE PDYYLDEAGR CTACVSCSRD DLVEKTPCAW NSSRTCECRP GMICATSATN SCARCVPYPI CAAETVTKPQ DMAEKDTTFE APPLGTQPDC NPTPENGEAP ASTSPTQSLL VDSQASKTLP IPTSAPVALS STGK

Tumor necrosis factor receptor superfamily member 8 (CD30) is a member of the TNF-receptor superfamily. CD30 is expressed by activated (not by resting) T and B cells. CD30 interacts with TRAF2 and TRAF5 which mediate the signal transduction that leads to the activation of NF-kappaB. CD30 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

CD30 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 384 amino acids (19-379a.a.) and having a molecular mass of 40.8kDa. CD30 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function:transmembrane receptor activity

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:P28908
NCBI GenInfo Identifier:115978
NCBI Gene ID:943
NCBI Accession:P28908.1
UniProt Secondary Accession:P28908,Q6P4D9, B1AN79, B9EGD9, D3YTD8,
UniProt Related Accession:P28908
Molecular Weight:50,935 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 8
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 8
NCBI Official Symbol:TNFRSF8��
NCBI Official Synonym Symbols:CD30; Ki-1; D1S166E��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 8
UniProt Synonym Protein Names:CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30
UniProt Gene Name:TNFRSF8��
UniProt Entry Name:TNR8_HUMAN
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