Immunology Recombinant Proteins

Human CD3 Epsilon/CD3E Recombinant Protein (RPES5124)

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SKU:
RPES5124
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology

Description

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Human CD3 Epsilon/CD3E Recombinant Protein

T-Cell Surface Glycoprotein CD3 ? Chain (CD3?) is a single-pass type I membrane protein. CD3? contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3? is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

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