Immunology Recombinant Proteins
Human CD3 Epsilon/CD3E Recombinant Protein (RPES5124)
- SKU:
- RPES5124
Description
Human CD3 Epsilon/CD3E Recombinant Protein
T-Cell Surface Glycoprotein CD3 ? Chain (CD3?) is a single-pass type I membrane protein. CD3? contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3? is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
| Product Name: | Human CD3 Epsilon/CD3E Recombinant Protein (RPES5124) |
| Product Code: | RPES5124 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3e, CD3E, T3E,CD3 epsilon,IMD18 |
| Accession: | P07766 |
| Sequence: | Asp23-Asp126 |
| Fusion tag: | C-Fc |
| Activity: | Immobilized Human CD3E-Fc at 10µg/ml(100 ?l/well) can bind Anti-CD3. The ED50 of Human CD3E-Fc is 4.0 ug/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human T-cell surface glycoprotein CD3 epsilon chain is produced by our Mammalian expression system and the target gene encoding Asp23-Asp126 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 38.7 kDa |
| AP Mol Mass: | 40-50 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Immunology |
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