Human CD3 Epsilon/CD3E Recombinant Protein (RPES3250)
- SKU:
- RPES3250
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human CD3 Epsilon/CD3E Recombinant Protein
T-Cell Surface Glycoprotein CD3 ? Chain (CD3?) is a single-pass type I membrane protein. CD3? contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3? is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
| Product Name: | Human CD3 Epsilon/CD3E Recombinant Protein (RPES3250) |
| Product Code: | RPES3250 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3e, CD3E, T3E,CD3 epsilon,IMD18 |
| Accession: | NP_000724.1 |
| Sequence: | Asp23-Asp126 |
| Fusion tag: | C-6His |
| Activity: | Immobilized Human CD3E-His at 10 µg/ml(100 ?l/well) can bind Human Anti-CD3. The ED50 of Human CD3E-His is 3.9 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human T-Cell Surface Glycoprotein CD3 epsilon Chain is produced by our Mammalian expression system and the target gene encoding Asp23-Asp126 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 12.8 kDa |
| AP Mol Mass: | 18 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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