CD Antigens Recombinant Proteins
Human CD28 Recombinant Protein (RPPB3037)
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- SKU:
- RPPB3037
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10747
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD28 Recombinant Protein |
| Product Code: | RPPB3037 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD28 |
| Synonyms: | T-cell-specific surface glycoprotein CD28, TP44, CD_antigen: CD28, T-cell-specific surface glycoprotein CD28 isoform 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CD28 protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPNKILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH |
CD28 co-stimulation is necessary for CD4 positive T-cell proliferation & survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence.
CD28 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 376 amino acids (19-152a.a.) and having a molecular mass of 42.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). CD28 is expressed with a 242 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). |
| NCBI Summary: | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P10747 |
| NCBI GenInfo Identifier: | 115973 |
| NCBI Gene ID: | 940 |
| NCBI Accession: | P10747.1 |
| UniProt Secondary Accession: | P10747,Q13964, Q52M23, Q70WG0, Q8NI54, Q8NI55, Q8NI56 Q8WXJ2, Q9BYV0, A8KAC1, |
| UniProt Related Accession: | P10747 |
| Molecular Weight: | 26,186 Da |
| NCBI Full Name: | T-cell-specific surface glycoprotein CD28 |
| NCBI Synonym Full Names: | CD28 molecule |
| NCBI Official Symbol: | CD28�� |
| NCBI Official Synonym Symbols: | Tp44�� |
| NCBI Protein Information: | T-cell-specific surface glycoprotein CD28 |
| UniProt Protein Name: | T-cell-specific surface glycoprotein CD28 |
| UniProt Synonym Protein Names: | TP44; CD_antigen: CD28 |
| Protein Family: | T-cell-specific surface glycoprotein |
| UniProt Gene Name: | CD28�� |
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