CD Antigens Recombinant Proteins

Human CD200R1 Recombinant Protein (RPPB3111)

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SKU:
RPPB3111
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8TD46
Research Area:
CD Antigens

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human CD200R1 Recombinant Protein
Product Code:RPPB3111
Size:5µg
Species:Human
Target:CD200R1
Synonyms:Cell surface glycoprotein CD200 receptor 1 isoform d, CD200R1, CD200R, HCRTR2, MOX2R, OX2R, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, Cd200r1, Mox2r, Ox2r.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:CD200R1 protein solution (0.25mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADLSSSLCMD EKQITQNYSK VLAEVNTSWP VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYKK ETNETKETNC TDERITWVSR PDQNSDLQIR TVAITHDGYY RCIMVTPDGN FHRGYHLQVL VTPEVTLFQN RNRTAVCKAV AGKPAAHISW IPEGDCATKQ EYWSNGTVTV KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH

CD200R1, also known as cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 inhibitory signaling pathway has been involved in taking a prominent role in limiting inflammation in a broad range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, in addition to inducible nitric oxide synthase in response to selected stimuli.

CD200R1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 462 amino acids (24-243 a.a.) and having a molecular mass of 51.9kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). CD200R1 is expressed with 242 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CD200R: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Belongs to the CD200R family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: plasma membrane; receptor complex

Molecular Function:protein binding

Biological Process: regulation of immune response

NCBI Summary:This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TD46
NCBI GenInfo Identifier:26006823
NCBI Gene ID:131450
NCBI Accession:Q8TD46.2
UniProt Secondary Accession:Q8TD46,Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45 Q8TD52, B3KWZ9, E9PCM9,
UniProt Related Accession:Q8TD46
Molecular Weight:39,056 Da
NCBI Full Name:Cell surface glycoprotein CD200 receptor 1
NCBI Synonym Full Names:CD200 receptor 1
NCBI Official Symbol:CD200R1��
NCBI Official Synonym Symbols:OX2R; MOX2R; CD200R; HCRTR2��
NCBI Protein Information:cell surface glycoprotein CD200 receptor 1
UniProt Protein Name:Cell surface glycoprotein CD200 receptor 1
UniProt Synonym Protein Names:CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1
Protein Family:Cell surface glycoprotein CD200 receptor
UniProt Gene Name:CD200R1��
UniProt Entry Name:MO2R1_HUMAN
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