CD Antigens Recombinant Proteins

Human CD1A Recombinant Protein (RPPB3010)

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RPPB3010

Description

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Product Name:Human CD1A Recombinant Protein
Product Code:RPPB3010
Size:5µg
Species:Human
Target:CD1A
Synonyms:T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, R4, T6; CD1, FCB6, HTA1, CD1A.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CD1A protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4), and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:ADPDGLKEPL SFHVTWIASF YNHSWKQNLV SGWLSDLQTH TWDSNSSTIV FLCPWSRGNF SNEEWKELET LFRIRTIRSF EGIRRYAHEL QFEYPFEIQV TGGCELHSGK VSGSFLQLAY QGSDFVSFQN NSWLPYPVAG NMAKHFCKVL NQNQHENDIT HNLLSDTCPR FILGLLDAGK AHLQRQVKPE AWLSHGPSPG PGHLQLVCHV SGFYPKPVWV MWMRGEQEQQ GTQRGDILPS ADGTWYLRAT LEVAAGEAAD LSCRVKHSSL EGQDIVLYWE HHSSVHHHHH H

CD1a is a transmembrane glycoproteins, which is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. CD1a mediates the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

CD1A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 291 amino acids (19-300a.a.) and having a molecular mass of 33.2kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). CD1A is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
NCBI Summary:This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:P06126
NCBI GenInfo Identifier:288558852
NCBI Gene ID:909
NCBI Accession:P06126.4
UniProt Related Accession:P06126
Molecular Weight:
NCBI Full Name:T-cell surface glycoprotein CD1a
NCBI Synonym Full Names:CD1a molecule
NCBI Official Symbol:CD1A��
NCBI Official Synonym Symbols:R4; T6; CD1; FCB6; HTA1��
NCBI Protein Information:T-cell surface glycoprotein CD1a
UniProt Protein Name:T-cell surface glycoprotein CD1a
UniProt Synonym Protein Names:T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a
Protein Family:CD109 antigen
UniProt Gene Name:CD1A��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P06126
Research Area:
CD Antigens
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