CD Antigens Recombinant Proteins
Human CD160 Recombinant Protein (RPPB3107)
- SKU:
- RPPB3107
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95971
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD160 Recombinant Protein |
| Product Code: | RPPB3107 |
| Size: | 5µg |
| Species: | Human |
| Target: | CD160 |
| Synonyms: | CD160 Molecule, CD160 Antigen, Natural Killer Cell Receptor BY55, BY55, Natural Killer Cell Receptor, Immunoglobulin Superfamily Member , CD160 Transmembrane Isoform, CD160-Delta Ig, NK28, NK1, CD160. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CD160 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLINITSSA SQEGTRLNLI CTVWHKKEEA EGFVVFLCKD RSGDCSPETS LKQLRLKRDP GIDGVGEISS QLMFTISQVT PLHSGTYQCC ARSQKSGIRL QGHFFSILFT ETGNYTVTGL KQRQHLEFSH NEGTLSHHHH HH |
CD160 antigen (CD160) is a human natural killer (NK)-cell-activating receptor which is also expressed on T-cell subsets. CD160 is a tumor-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for therapeutic manipulation and monitoring of minimal residual disease. CD160 was identified as a T cell coinhibitory molecule which interacts with the herpesvirus entry mediator (HVEM) on antigen-presenting cells to deliver a potent inhibitory signal to CD4(+) T cells. CD160 expression is strongly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 has a broad specificity for binding to both classical and nonclassical MHC class I molecules.
CD160 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 142 amino acids (27-159a.a.) and having a molecular mass of 15.9kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). CD160 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Receptor showing broad specificity for both classical and non-classical MHC class I molecules. |
| NCBI Summary: | CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95971 |
| NCBI GenInfo Identifier: | 17372903 |
| NCBI Gene ID: | 11126 |
| NCBI Accession: | O95971.1 |
| UniProt Related Accession: | O95971 |
| Molecular Weight: | 19,810 Da |
| NCBI Full Name: | CD160 antigen |
| NCBI Synonym Full Names: | CD160 molecule |
| NCBI Official Symbol: | CD160�� |
| NCBI Official Synonym Symbols: | NK1; BY55; NK28�� |
| NCBI Protein Information: | CD160 antigen |
| UniProt Protein Name: | CD160 antigen |
| UniProt Synonym Protein Names: | Natural killer cell receptor BY55; CD_antigen: CD160 |
| Protein Family: | CD160 antigen |
| UniProt Gene Name: | CD160�� |
Related Products
Human CD160/BY55 Recombinant Protein (RPES3233)
Human CD160/BY55 Recombinant Protein (RPES3769)
Immunology Recombinant Proteins
Human CD160/BY55 Recombinant Protein (RPES4986)
Immunology Recombinant Proteins
Human CD160 Recombinant Protein (His tag) (RPES5970)
Human CD160 Recombinant Protein (hFc Tag) (HDPT0150)
Immune Checkpoint Recombinant Proteins
Human CD160 Recombinant Protein (His tag) (RPES6578)
Human CD160 Recombinant Protein (His Tag) (HDPT0154)
Immune Checkpoint Recombinant Proteins
Rhesus macaque CD160 Recombinant Protein (RPES3922)
