Cell Biology Recombinant Proteins
Human CD155/PVR/NECL5 Recombinant Protein (RPES0478)
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- SKU:
- RPES0478
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Biology
Description
system_update_altDatasheet
Human CD155/PVR/NECL5 Recombinant Protein
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (?; β; ?; and ?) with identical extracellular domains.
| Product Name: | Human CD155/PVR/NECL5 Recombinant Protein (RPES0478) |
| Product Code: | RPES0478 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Poliovirus Receptor, Nectin-Like Protein 5, NECL-5, CD155, PVR, PVS |
| Accession: | P15151 |
| Sequence: | Trp21-Asn343(Ile340Met) |
| Fusion tag: | C-His |
| Activity: | Immobilized Human TIGIT-Fc(Cat: PKSH033510) at 5µg/ml(100 ?l/well) can bind Human PVR-His. The ED50 of Human PVR-His is 11.66 ug/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human NECL5 is produced by our Mammalian expression system and the target gene encoding Trp21-Asn343(Ile340Met) is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 36.13 kDa |
| AP Mol Mass: | 58 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.4. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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