Human CD122/IL-2RB Recombinant Protein (RPES1420)
- SKU:
- RPES1420
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human CD122/IL-2RB Recombinant Protein
Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
| Product Name: | Human CD122/IL-2RB Recombinant Protein (RPES1420) |
| Product Code: | RPES1420 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | CD122,IL15RB,P70-75 |
| Accession: | NP_000869.1 |
| Sequence: | Met 1-Asp 239 |
| Fusion tag: | C-Fc |
| Activity: | 1.Measured by its ability to bind biotinylated recombinant rat IL2 in a functional ELISA.2. Using the Octet RED System, the affinity constant (Kd) of Human IL2RB-Fc bound to Human IL2 was 0.8nM. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Asp 239) of human IL2 R? (NP_000869.1) precursor was expressed with the C-terminal fused Fc region of human IgG1. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 51.6 kDa |
| AP Mol Mass: | 60-65 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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