Human CD107a/LAMP-1 Monoclonal Antibody (FITC Conjugated) [H4A3](AGEL1774)

Name: Human CD107a/LAMP-1 Monoclonal Antibody (FITC Conjugated) [H4A3](AGEL1774)
SKU: AGEL1774
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OverviewAntibody Name:Human CD107a/LAMP-1 Monoclonal Antibody (PE Conjugated)Antibody Code:AGEL1775Size:50 TestsClone:H4A3

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OverviewProduct Name:PE/AF594 Anti-Human CD107a/LAMP-1 Antibody [H4A3]Product Code:AGEL3268Size:20 Tests, 100 Tests, 200 TestsClone No:

OverviewAntibody Name:Human CD57 Monoclonal Antibody (FITC Conjugated)Antibody Code:AGEL1032Size:50 TestsClone:HNK-1Sy

OverviewAntibody Name:Human CD25 Monoclonal Antibody (FITC Conjugated)Antibody Code:AGEL2016Size:50 TestsClone:BC96Syn

system_update_altDatasheetOverviewAnti

system_update_altDatasheetOverviewAnti

Concentration:	5uL
Isotype:	IgG2a,k
Conjugation:	FITC
Applications:	FC
Recommended Dilution:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:	PBS with 0.05% Proclin300, 1% BSA
Storage:	Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Gene ID:	3916
Uniprot:	P11279
Background:	CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.