Human CCND2 / Cyclin D2 ELISA Kit

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SKU:
HUFI02299
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P30279
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
CCND2, G1, S-specific cyclin-D2
Reactivity:
Human
Research Area:
Cell Cycle

Description

Human CCND2 / Cyclin D2 ELISA Kit

CCND2 / Cyclin D2 belongs to the highly conserved cyclin family, and acts as a cell cycle regulator of CDK kinases. CCND2 / Cyclin D2 forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. CCND2 / Cyclin D2 has also been shown to be involved in the phosphorylation of tumor suppressor protein Rb. High levels of expression of CCND2 / Cyclin D2 was observed in ovarian and testicular tumors. Mutations in CCND2 / Cyclin D2 are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).

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