Human CCDC101 Recombinant Protein (RPPB2997)
- SKU:
- RPPB2997
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96ES7
Description
| Product Name: | Human CCDC101 Recombinant Protein |
| Product Code: | RPPB2997 |
| Size: | 10µg |
| Species: | Human |
| Target: | CCDC101 |
| Synonyms: | coiled-coil domain containing protein 101, SAGA-associated factor 29 homolog, SGF29, STAF36, FLJ32446. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CCDC101 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR GLYTTAKADA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVARPGD KVAARVKAVD GDEQWILAEV VSYSHATNKY EVDDIDEEGK ERHTLSRRRV IPLPQWKANP ETDPEALFQK EQLVLALYPQ TTCFYRALIH APPQRPQDDY SVLFEDTSYA DGYSPPLNVA QRYVVACKEP KKK |
CCDC101 is known as a subunit of the SAGA (Spt-Ada-Gcn5 acetyltransferase) histone acetyltransferase complex in Saccharomyces cerevisiae. CCDC101 is conserved from yeast to humans.
CCDC101 Human Recombinant produced in E. coli is a single polypeptide chain containing 313 amino acids (1-293) and having a molecular mass of 35.4kDa.CCDC101 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCDC101: Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation. Belongs to the SGF29 family.Chromosomal Location of Human Ortholog: 16p11.2Molecular Function: methylated histone residue binding; protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010] |
| UniProt Code: | Q96ES7 |
| NCBI GenInfo Identifier: | 74731608 |
| NCBI Gene ID: | 112869 |
| NCBI Accession: | Q96ES7.1 |
| UniProt Secondary Accession: | Q96ES7,Q96MF5 |
| UniProt Related Accession: | Q96ES7 |
| Molecular Weight: | 33,238 Da |
| NCBI Full Name: | SAGA-associated factor 29 |
| NCBI Synonym Full Names: | SAGA complex associated factor 29 |
| NCBI Official Symbol: | SGF29�� |
| NCBI Official Synonym Symbols: | STAF36; TDRD29; CCDC101�� |
| NCBI Protein Information: | SAGA-associated factor 29 |
| UniProt Protein Name: | SAGA-associated factor 29 |
| UniProt Synonym Protein Names: | Coiled-coil domain-containing protein 101; SAGA complex-associated factor 29 |
| Protein Family: | |
| UniProt Gene Name: | SGF29�� |
| UniProt Entry Name: | SGF29_HUMAN |
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