Enzymes Recombinant Proteins

Human CCBL1 Recombinant Protein (RPPB1478)

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RPPB1478

Description

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Product Name:Human CCBL1 Recombinant Protein
Product Code:RPPB1478
Size:20µg
Species:Human
Target:CCBL1
Synonyms:Cysteine Conjugate-Beta Lyase, Cytoplasmic, GlutamineTransaminase K, Cysteine Conjugate-Beta Lyase; Cytoplasmic (GlutamineTransaminase K, Kyneurenine Aminotransferase), Kynurenine--OxoglutarateTransaminase I, Glutamine--Phenylpyruvate Transaminase, Cysteine-S-ConjugateBeta-Lyase, Kynurenine Aminotransferase I, Kyneurenine Aminotransferase, KATI, GTK,Glutamine-Phenylpyruvate Aminotransferase, Kynurenine--OxoglutarateTransaminase 1, Beta-Lysase, Kidney, EC 4.4.1.13, EC 2.6.1.64, EC 2.6.1.7, KAT1,Kynurenine--oxoglutarate transaminase 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CCBL1 protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSMAKQLQARRLDGIDYNP WVEFVKLASE HDVVNLGQGF PDFPPPDFAV EAFQHAVSGD FMLNQYTKTF GYPPLTKILASFFGELLGQE IDPLRNVLVT VGGYGALFTA FQALVDEGDE VIIIEPFFDC YEPMTMMAGG RPVFVSLKPGPIQNGELGSS SNWQLDPMEL AGKFTSRTKA LVLNTPNNPL GKVFSREELE LVASLCQQHD VVCITDEVYQWMVYDGHQHI SIASLPGMWE RTLTIGSAGK TFSATGWKVG WVLGPDHIMK HLRTVHQNSV FHCPTQSQAAVAESFEREQL LFRQPSSYFV QFPQAMQRCR DHMIRSLQSV GLKPIIPQGS YFLITDISDF KRKMPDLPGAVDEPYDRRFV KWMIKNKGLV AIPVSIFYSV PHQKHFDHYI RFCFVKDEAT LQAMDEKLRK WKVEL

Cysteine Conjugate-Beta Lyase Cytoplasmic also known as CCBL1 is a member of the class-I pyridoxal-phosphate-dependent aminotransferase family. CCBL1 catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) it also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Furthermore, CCBL1 catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)� cysteine, resulting in the cleavage of the C-S or C-Se bond.

CCBL1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 445 amino acids (1-422 a.a) andhaving a molecular mass of 50.3kDa.CCBL1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 4.4.1.13; Lyase; EC 2.6.1.7; Transferase; EC 2.6.1.64

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function:glutamine-pyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; phenylalanine(histidine) transaminase activity; protein binding; protein homodimerization activity; transaminase activity

Biological Process: amino acid biosynthetic process; amino acid derivative metabolic process; L-phenylalanine catabolic process; tryptophan catabolic process

NCBI Summary:This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q16773
NCBI GenInfo Identifier:46396284
NCBI Gene ID:883
NCBI Accession:Q16773.1
UniProt Secondary Accession:Q16773,Q5T275, Q8N191,
UniProt Related Accession:Q16773
Molecular Weight:27,420 Da
NCBI Full Name:Kynurenine--oxoglutarate transaminase 1
NCBI Synonym Full Names:kynurenine aminotransferase 1
NCBI Official Symbol:KYAT1��
NCBI Official Synonym Symbols:GTK; KAT1; KATI; CCBL1��
NCBI Protein Information:kynurenine--oxoglutarate transaminase 1
UniProt Protein Name:Kynurenine--oxoglutarate transaminase 1
UniProt Synonym Protein Names:Cysteine-S-conjugate beta-lyase (EC:4.4.1.13); Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase (EC:2.6.1.64); Kynurenine aminotransferase 1
UniProt Gene Name:KYAT1��
UniProt Entry Name:KAT1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16773
Research Area:
Enzymes
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