Human CBX3 / Chromobox Homolog 3 ELISA Kit

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SKU:
HUFI02293
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q13185
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
CBX3
Reactivity:
Human
Research Area:
Cell Biology

Description

Human CBX3 / Chromobox Homolog 3 ELISA

The inner nuclear membrane is adjacent to the nuclear lamina and heterochromatin at the nuclear envelope. CBX3 binds DNA and is involved in heterochromatin formation. CBX3 can also interact with lamin B receptor, an integral membrane protein that may be found within the inner nuclear membrane. The interrelationship between heterochromatin and the inner nuclear membrane's twin binding properties may be accounted for by CBX3's double-binding capabilities. CBX3 binds methylated H3 tails at Lys-9 sites in histone H3. CBX3 is also recruited to regions of UV-induced DNA damage and double strand breaks. CBX3 defects are associated with several different diseases, including Hyperoxaluria nd Carbohydrate Metabolic Disorder.

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