Human CBFB HUman Recombinant Protein (RPPB2987)
- SKU:
- RPPB2987
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13951
Description
| Product Name: | Human CBFB HUman Recombinant Protein |
| Product Code: | RPPB2987 |
| Size: | 10µg |
| Species: | Human |
| Target: | CBFB HUman |
| Synonyms: | PEBP2B, polyomavirus enhancer binding protein b, PEA2, CBF-beta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | 0.5mg/ml solution containing 20mM MES pH-6, 0.1mM PMSF & 10% glycerol. |
| Stability: | CBFB Human although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFPASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSHREEMEVRVSQ LLAVTGKKTT RP |
CBFB beta subunit is a heterodimeric core-binding transcription factor that is part of the PEBP2/CBF transcription factor family which controls a host of genes particulary to hematopoiesis and osteogenesis. CBFB is a non-DNA binding regulatory subunit which increases DNA binding by alpha subunit.
CBFB Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (1-202 a.a.) and having a molecular mass of 23.6 kDa. The CBFB is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CBFB: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1. A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11. Belongs to the CBF-beta family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: membrane; nucleus Molecular Function:protein binding; DNA binding; transcription coactivator activity; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; osteoblast differentiation; lymphocyte differentiation; cell maturation; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13951 |
| NCBI GenInfo Identifier: | 2498753 |
| NCBI Gene ID: | 865 |
| NCBI Accession: | Q13951.2 |
| UniProt Secondary Accession: | Q13951,Q13124, Q9HCT2, A8K347, |
| UniProt Related Accession: | Q13951 |
| Molecular Weight: | 21,991 Da |
| NCBI Full Name: | Core-binding factor subunit beta |
| NCBI Synonym Full Names: | core-binding factor, beta subunit |
| NCBI Official Symbol: | CBFB�� |
| NCBI Official Synonym Symbols: | PEBP2B�� |
| NCBI Protein Information: | core-binding factor subunit beta; CBF-beta; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; polyomavirus enhancer-binding protein 2 beta subunit; polyomavirus enhancer binding protein 2, beta subunit |
| UniProt Protein Name: | Core-binding factor subunit beta |
| UniProt Synonym Protein Names: | Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit |
| Protein Family: | Core-binding factor |
| UniProt Gene Name: | CBFB�� |
| UniProt Entry Name: | PEBB_HUMAN |
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