Human Cathepsin S/CTSS Recombinant Protein (RPES3899)
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- SKU:
- RPES3899
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human Cathepsin S/CTSS Recombinant Protein
Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimers disease(AD) and Down Syndrome (DS).
| Product Name: | Human Cathepsin S/CTSS Recombinant Protein (RPES3899) |
| Product Code: | RPES3899 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Cathepsin S,CTSS,CTSS,MGC3886 |
| Accession: | P25774 |
| Sequence: | Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide) |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 The specific activity is 9063.642 pmol/min/µg. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Cathepsin S is produced by our Mammalian expression system and the target geneencoding Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide) is expressed with a 6His tag atthe C-terminus. |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
| Mol Mass: | 36.9&25&11.2 kDa |
| AP Mol Mass: | 37-40&26-28&14-16 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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