Human Cathepsin D/CTSD Recombinant Protein (RPES4634)
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- SKU:
- RPES4634
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human Cathepsin D/CTSD Recombinant Protein
The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to; but narrower than; that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family
| Product Name: | Human Cathepsin D/CTSD Recombinant Protein (RPES4634) |
| Product Code: | RPES4634 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Cathepsin D, CTSD,CLN10,CPSD,HEL-S-130P |
| Accession: | P07339 |
| Sequence: | Leu21-Leu412 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Cathepsin D is produced by our Mammalian expression system and the target gene encoding Leu21-Leu412 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 43.8 kDa |
| AP Mol Mass: | 50 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM MES; 150mM NaCl; pH 5.5. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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