Human CARD18 Recombinant Protein (RPPB2984)
- SKU:
- RPPB2984
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P57730
Description
| Product Name: | Human CARD18 Recombinant Protein |
| Product Code: | RPPB2984 |
| Size: | 10µg |
| Species: | Human |
| Target: | CARD18 |
| Synonyms: | Caspase recruitment domain family member 18, ICEBERG, pseudo-ICE, UNQ5804, Caspase-1 inhibitor Iceberg, ICEBERG caspase-1 inhibitor. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The LSM3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH |
CARD18 belongs to the death-domain-fold superfamily which is induced by proinflammatory stimuli. CARD18 contains basically only a Caspase recruitment domain, inhibits generation of IL-1b by cooperating with caspase-1 and inhibiting connotation with RIP 2. The connotation of CARD18 to caspase-1 is enabled by the charge-charge interactions between the prodomain of caspase-1 and the surface charge of CARD18.
CARD18 Human Recombinant produced in�E. coli is a single polypeptide chain containing 110 amino acids (1-90) and having a molecular mass of 12.3kDa.CARD18 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P57730 |
| NCBI GenInfo Identifier: | 10954343 |
| NCBI Gene ID: | 59082 |
| NCBI Accession: | NP_067546.1 |
| UniProt Secondary Accession: | P57730,A2RRF8 |
| UniProt Related Accession: | P57730 |
| Molecular Weight: | 10,138 Da |
| NCBI Full Name: | caspase recruitment domain-containing protein 18 |
| NCBI Synonym Full Names: | caspase recruitment domain family member 18 |
| NCBI Official Symbol: | CARD18�� |
| NCBI Official Synonym Symbols: | ICEBERG; UNQ5804; pseudo-ICE�� |
| NCBI Protein Information: | caspase recruitment domain-containing protein 18 |
| UniProt Protein Name: | Caspase recruitment domain-containing protein 18 |
| UniProt Synonym Protein Names: | Caspase-1 inhibitor Iceberg |
| Protein Family: | |
| UniProt Gene Name: | CARD18�� |
| UniProt Entry Name: | CAR18_HUMAN |
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