Human CARD17 Recombinant Protein (RPPB2983)
- SKU:
- RPPB2983
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q5XLA6
Description
| Product Name: | Human CARD17 Recombinant Protein |
| Product Code: | RPPB2983 |
| Size: | 20µg |
| Species: | Human |
| Target: | CARD17 |
| Synonyms: | CARD17, Caspase Recruitment Domain Family, Member 17, Caspase recruitment domain-containing protein 17, INCA, Caspase-1 inhibitor INCA, Inhibitory caspase recruitment domain protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CARD17 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMADKVLK EKRKQFIRSV GEGTINGLLG ELLETRVLSQ EEIEIVKCEN ATVMDKARAL LDSVIRKGAP ACQICITYIC EEDSHLAGTL GLSAGPTSGN HLTTQDSQIV LPS |
Caspase Recruitment Domain Family, Member 17 (CARD17) is a regulator of procaspase-1/CASP1 activation involved in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release throughout inflammation. CARD17 inhibits the release of IL1B in reaction to LPS in monocytes. Though, unlike CASP1, CARD17 do not induce NF-kappa-B activation.
CARD17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-110) and having a molecular mass of 14.3 kDa.CARD17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5XLA6 |
| NCBI GenInfo Identifier: | 55925612 |
| NCBI Gene ID: | 440068 |
| NCBI Accession: | NP_001007233.1 |
| UniProt Secondary Accession: | Q5XLA6 |
| UniProt Related Accession: | Q5XLA6 |
| Molecular Weight: | 11,868 Da |
| NCBI Full Name: | caspase recruitment domain-containing protein 17 |
| NCBI Synonym Full Names: | caspase recruitment domain family, member 17 |
| NCBI Official Symbol: | CARD17�� |
| NCBI Official Synonym Symbols: | INCA�� |
| NCBI Protein Information: | caspase recruitment domain-containing protein 17; Inhibitory CARD; caspase-1 inhibitor INCA; inhibitory caspase recruitment domain (CARD) protein; inhibitory caspase recruitment domain protein |
| UniProt Protein Name: | Caspase recruitment domain-containing protein 17 |
| UniProt Synonym Protein Names: | Caspase-1 inhibitor INCA; Inhibitory caspase recruitment domain protein |
| Protein Family: | Inclusion membrane protein |
| UniProt Gene Name: | CARD17�� |
| UniProt Entry Name: | CAR17_HUMAN |
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