Human CAPZA2 Recombinant Protein (RPPB2982)
- SKU:
- RPPB2982
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P47755
Description
| Product Name: | Human CAPZA2 Recombinant Protein |
| Product Code: | RPPB2982 |
| Size: | 20µg |
| Species: | Human |
| Target: | CAPZA2 |
| Synonyms: | Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2, F-Actin Capping Protein Alpha-2 Subunit, CapZ Alpha-2, CAPPA, CAPZ2, F-Actin-Capping Protein Subunit Alpha-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | CAPZA2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, and 0.4M UREA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMADLEEQ LSDEEKVRIA AKFIIHAPPG EFNEVFNDVR LLLNNDNLLR EGAAHAFAQY NLDQFTPVKI EGYEDQVLIT EHGDLGNGKF LDPKNRICFK FDHLRKEATD PRPCEVENAV ESWRTSVETA LRAYVKEHYP NGVCTVYGKK IDGQQTIIAC IESHQFQAKN FWNGRWRSEW KFTITPSTTQ VVGILKIQVH YYEDGNVQLV SHKDIQDSLT VSNEVQTAKE FIKIVEAAEN EYQTAISENY QTMSDTTFKA LRRQLPVTRT KIDWNKILSY KIGKEMQNA |
Capping Protein (Actin Filament) Muscle Z-Line, Alpha 2 also known as CAPZA2 belongs the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. Among the diseases associated with CAPZA2 are endocarditis, and cervicitis.
CAPZA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (1-286 a.a) and having a molecular mass of 35.3kDa.CAPZA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CAPZA2: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Belongs to the F-actin-capping protein alpha subunit family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 7q31.2-q31.3 Cellular Component: cortical cytoskeleton; F-actin capping protein complex; membrane; extracellular region; cytosol; actin cytoskeleton Molecular Function:actin binding Biological Process: innate immune response; protein complex assembly; cell motility; barbed-end actin filament capping; blood coagulation |
| NCBI Summary: | The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P47755 |
| NCBI GenInfo Identifier: | 1345695 |
| NCBI Gene ID: | 830 |
| NCBI Accession: | P47755.3 |
| UniProt Secondary Accession: | P47755,B4DG50, |
| UniProt Related Accession: | P47755 |
| Molecular Weight: | 286 |
| NCBI Full Name: | F-actin-capping protein subunit alpha-2 |
| NCBI Synonym Full Names: | capping protein (actin filament) muscle Z-line, alpha 2 |
| NCBI Official Symbol: | CAPZA2�� |
| NCBI Official Synonym Symbols: | CAPZ; CAPPA2�� |
| NCBI Protein Information: | F-actin-capping protein subunit alpha-2; capZ alpha-2; F-actin capping protein alpha-2 subunit |
| UniProt Protein Name: | F-actin-capping protein subunit alpha-2 |
| UniProt Synonym Protein Names: | CapZ alpha-2 |
| Protein Family: | F-actin-capping protein |
| UniProt Gene Name: | CAPZA2�� |
| UniProt Entry Name: | CAZA2_HUMAN |
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