Human CANT1 Recombinant Protein (RPPB2976)

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SKU:
RPPB2976
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WVQ1

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human CANT1 Recombinant Protein
Product Code:RPPB2976
Size:10µg
Species:Human
Target:CANT1
Synonyms:Soluble calcium-activated nucleotidase 1, SCAN-1, Apyrase homolog, Putative MAPK-activating protein PM09, Putative NF-kappa-B-activating protein 107, CANT1, SHAPY, DBQD, SCAN1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CANT1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 50mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMRPAPG RPPTHNAHNW RLGQAPANWY NDTYPLSPPQ RTPAGIRYRI AVIADLDTES RAQEENTWFS YLKKGYLTLS DSGDKVAVEW DKDHGVLESH LAEKGRGMEL SDLIVFNGKL YSVDDRTGVV YQIEGSKAVP WVILSDGDGT VEKGFKAEWL AVKDERLYVG GLGKEWTTTT GDVVNENPEW VKVVGYKGSV DHENWVSNYN ALRAAAGIQP PGYLIHESAC WSDTLQRWFF LPRRASQERY SEKDDERKGA NLLLSASPDF GDIAVSHVGA VVPTHGFSSF KFIPNTDDQI IVALKSEEDS GRVASYIMAF TLDGRFLLPE TKIGSVKYEG IEFI

Calcium-activated nucleotidase 1 (CANT1) is a member of the apyrase family. The CANT1 protein is calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is as follows: UDP > GDP > UTP > GTP. Moreover, CANT1 has a very low activity towards ADP and an even lower activity towards ATP. As well as it doesn�t hydrolyze AMP and GMP. CANT1�s specific function is yet unknown, nevertheless its substrates are involved in several key signaling functions, including Ca2+ release, through activation of pyrimidinergic signaling. Mutations in the CANT1 gene are linked with Desbuquois dysplasia with hand anomalies.

CANT1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 364 amino acids (63-401 a.a.) and having a molecular mass of 40.5kDa. CANT1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - pyrimidine; EC 3.6.1.6; Hydrolase; Endoplasmic reticulum; Nucleotide Metabolism - purine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.3

Molecular Function:guanosine-diphosphatase activity; signal transducer activity; uridine-diphosphatase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process

Disease: Desbuquois Dysplasia 1

NCBI Summary:This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
UniProt Code:Q8WVQ1
NCBI GenInfo Identifier:66774052
NCBI Gene ID:124583
NCBI Accession:Q8WVQ1.1
UniProt Secondary Accession:Q8WVQ1,Q7Z2J7, Q8NG05, Q8NHP0, Q9BSD5, B4DJ54,
UniProt Related Accession:Q8WVQ1
Molecular Weight:38,946 Da
NCBI Full Name:Soluble calcium-activated nucleotidase 1
NCBI Synonym Full Names:calcium activated nucleotidase 1
NCBI Official Symbol:CANT1��
NCBI Official Synonym Symbols:DBQD; DBQD1; SCAN1; SHAPY; SCAN-1��
NCBI Protein Information:soluble calcium-activated nucleotidase 1
UniProt Protein Name:Soluble calcium-activated nucleotidase 1
UniProt Synonym Protein Names:Apyrase homolog; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107
Protein Family:Soluble calcium-activated nucleotidase
UniProt Gene Name:CANT1��
UniProt Entry Name:CANT1_HUMAN
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