Enzymes Recombinant Proteins

Human CAMK2N1 Recombinant Protein (RPPB2974)

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SKU:
RPPB2974
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q7Z7J9
Research Area:
Enzymes

Description

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Product Name:Human CAMK2N1 Recombinant Protein
Product Code:RPPB2974
Size:10µg
Species:Human
Target:CAMK2N1
Synonyms:PRO1489; RP11-401M16.1, Calcium/calmodulin-dependent protein kinase II inhibitor 1, CaMKII inhibitory protein alpha, CaMKIIN-alpha, CAMK2N1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CAMK2N1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSEVLPY GDEKLSPYGD GGDVGQIFSC RLQDTNNFFG AGQNKRPPKL GQIGRSKRVV IEDDRIDDVL KNMTDKAPPG V

Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1 (CAMK2N1), which interacts with CAMK2B, is a part of the CAMK2N family. CAMK2N1 is also interacts with CAMK2A in a way which requires CAMK2A activation by Ca2+. CAMK2N1 is potent and specific inhibitor of CaM-kinase II (CAMK2).

CAMK2N1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (1-78 a.a) and having a molecular mass of 10.9kDa. CAMK2N1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CAMK2N1: Potent and specific inhibitor of CaM-kinase II (CAMK2). Belongs to the CAMK2N family.Protein type: Inhibitor; Protein kinase, regulatory subunitChromosomal Location of Human Ortholog: 1p36.12Cellular Component: postsynaptic membrane; cell soma; postsynaptic density; dendrite; cell junctionMolecular Function: calcium-dependent protein kinase inhibitor activity; protein kinase bindingBiological Process: negative regulation of protein kinase activity
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q7Z7J9
NCBI GenInfo Identifier:74750243
NCBI Gene ID:55450
NCBI Accession:Q7Z7J9.1
UniProt Secondary Accession:Q7Z7J9
UniProt Related Accession:Q7Z7J9
Molecular Weight:8,553 Da
NCBI Full Name:Calcium/calmodulin-dependent protein kinase II inhibitor 1
NCBI Synonym Full Names:calcium/calmodulin-dependent protein kinase II inhibitor 1
NCBI Official Symbol:CAMK2N1��
NCBI Official Synonym Symbols:PRO1489��
NCBI Protein Information:calcium/calmodulin-dependent protein kinase II inhibitor 1; CaMKIINalpha; caMKII inhibitory protein alpha; caMKIIN-alpha
UniProt Protein Name:Calcium/calmodulin-dependent protein kinase II inhibitor 1
UniProt Synonym Protein Names:CaMKII inhibitory protein alpha; CaMKIIN-alpha
Protein Family:Calcium/calmodulin-dependent protein kinase II inhibitor
UniProt Gene Name:CAMK2N1��
UniProt Entry Name:CK2N1_HUMAN
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