Human CALR3 Recombinant Protein (RPPB2970)
- SKU:
- RPPB2970
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96L12
Description
| Product Name: | Human CALR3 Recombinant Protein |
| Product Code: | RPPB2970 |
| Size: | 20µg |
| Species: | Human |
| Target: | CALR3 |
| Synonyms: | CRT2, FLJ25355, MGC26577, Calreticulin-3, Calreticulin-2, Calsperin, CALR3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CALR3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MTVYFQEEFL DGEHWRNRWL QSTNDSRFGH FRLSSGKFYG HKEKDKGLQT TQNGRFYAIS ARFKPFSNKG KTLVIQYTVK HEQKMDCGGG YIKVFPADID QKNLNGKSQY YIMFGPDICG FDIKKVHVIL HFKNKYHENK KLIRCKVDGF THLYTLILRP DLSYDVKIDG QSIESGSIEY DWNLTSLKKE TSPAESKDWE QTKDNKAQDW EKHFLDASTS KQSDWNGDLD GDWPAPMLQK PPYQDGLKPE GIHKDVWLHR KMKNTDYLTQ YDLSEFENIG AIGLELWQVR SGTIFDNFLI TDDEEYADNF GKATWGETKG PEREMDAIQA KEEMKKAREE EEEELLSGKI NRHEHYFNQF HRRNEL |
Calreticulin 3 (CALR3) belongs to the calreticulin (CRT) family which consists of calcium binding chaperones that are localized to the endoplasmic reticulum or sarcoplasmic reticulum in eukaryotes. CALR3, which is expressed mainly in testis, takes part in protein-folding, oligomeric assembly and quality control in the ER. CALR3 plays an important role as a cancer-testis antigen due to its frequent expression in many cancers.
CALR3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 366 amino acids (20-384 a.a) and having a molecular mass of 43kDa. CALR3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | calreticulin 3: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. CALR3 capacity for calcium- binding may be absent or much lower than that of CALR. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19). CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the calreticulin family.Protein type: Chaperone; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 19p13.11Cellular Component: endoplasmic reticulum lumenMolecular Function: unfolded protein binding; calcium ion binding; carbohydrate bindingBiological Process: protein folding; spermatogenesis; cell differentiationDisease: Cardiomyopathy, Familial Hypertrophic, 19 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q96L12 |
| NCBI GenInfo Identifier: | 116241279 |
| NCBI Gene ID: | 125972 |
| NCBI Accession: | Q96L12.2 |
| UniProt Secondary Accession: | Q96L12,Q96LN3, D9N574 |
| UniProt Related Accession: | Q96L12 |
| Molecular Weight: | |
| NCBI Full Name: | Calreticulin-3 |
| NCBI Synonym Full Names: | calreticulin 3 |
| NCBI Official Symbol: | CALR3�� |
| NCBI Official Synonym Symbols: | CRT2; CT93; CMH19�� |
| NCBI Protein Information: | calreticulin-3; calreticulin-2; calsperin; cancer/testis antigen 93 |
| UniProt Protein Name: | Calreticulin-3 |
| UniProt Synonym Protein Names: | Calreticulin-2; Calsperin |
| Protein Family: | Calreticulin |
| UniProt Gene Name: | CALR3�� |
| UniProt Entry Name: | CALR3_HUMAN |
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