Human CALML5 Recombinant Protein (RPPB5867)

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SKU:
RPPB5867
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NZT1

Description

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Product Name:Human CALML5 Recombinant Protein
Product Code:RPPB5867
Size:10µg
Species:Human
Target:CALML5
Synonyms:CLSP, Calmodulin-like skin protein, CALML5, Calmodulin-like protein 5.�
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:CALML5 filtered (0.4 �m) and lyophilized from 0.5mg/ml in 20 mM Tris buffer, 50 mM NaCl and 5% w/v trehalosa, pH 7.5.
Solubility:It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. CALML5 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHAS AGELTPEEEA QYKKAFSAVD TDGNGTINAQ ELGAALKATG KNLSEAQLRK LISEVDSDGD GEISFQEFLT AAKKARAGLE DLQVAFRAFD QDGDGHITVD ELRRAMAGLG QPLPQEELDA MIREADVDQD GRVNYEEFAR MLAQE

Calmodulin Like 5, also known as CALML5 is a part of the calmodulin family of calcium binding proteins. CALML5 undergoes a conformational change as a result of binding calcium. CALML5 is taking part in terminal differentiation of keratinocytes and encodes a calcium binding protein expressed in the epidermis.

CALML5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 2-146) containing 155 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 17.0kDa (calculated).�

UniProt Protein Function:Binds calcium. May be involved in terminal differentiation of keratinocytes.
NCBI Summary:This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NZT1
NCBI GenInfo Identifier:215273944
NCBI Gene ID:51806
NCBI Accession:Q9NZT1.2
UniProt Secondary Accession:Q9NZT1,Q5SQI3, Q8IXU8,
UniProt Related Accession:Q9NZT1
Molecular Weight:15,893 Da
NCBI Full Name:Calmodulin-like protein 5
NCBI Synonym Full Names:calmodulin like 5
NCBI Official Symbol:CALML5��
NCBI Official Synonym Symbols:CLSP��
NCBI Protein Information:calmodulin-like protein 5
UniProt Protein Name:Calmodulin-like protein 5
UniProt Synonym Protein Names:Calmodulin-like skin protein
UniProt Gene Name:CALML5��
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