Human CALML5 Recombinant Protein (RPPB5867)
- SKU:
- RPPB5867
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NZT1
Description
| Product Name: | Human CALML5 Recombinant Protein |
| Product Code: | RPPB5867 |
| Size: | 10µg |
| Species: | Human |
| Target: | CALML5 |
| Synonyms: | CLSP, Calmodulin-like skin protein, CALML5, Calmodulin-like protein 5.� |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | CALML5 filtered (0.4 �m) and lyophilized from 0.5mg/ml in 20 mM Tris buffer, 50 mM NaCl and 5% w/v trehalosa, pH 7.5. |
| Solubility: | It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. CALML5 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS AGELTPEEEA QYKKAFSAVD TDGNGTINAQ ELGAALKATG KNLSEAQLRK LISEVDSDGD GEISFQEFLT AAKKARAGLE DLQVAFRAFD QDGDGHITVD ELRRAMAGLG QPLPQEELDA MIREADVDQD GRVNYEEFAR MLAQE |
Calmodulin Like 5, also known as CALML5 is a part of the calmodulin family of calcium binding proteins. CALML5 undergoes a conformational change as a result of binding calcium. CALML5 is taking part in terminal differentiation of keratinocytes and encodes a calcium binding protein expressed in the epidermis.
CALML5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 2-146) containing 155 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 17.0kDa (calculated).�
| UniProt Protein Function: | Binds calcium. May be involved in terminal differentiation of keratinocytes. |
| NCBI Summary: | This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NZT1 |
| NCBI GenInfo Identifier: | 215273944 |
| NCBI Gene ID: | 51806 |
| NCBI Accession: | Q9NZT1.2 |
| UniProt Secondary Accession: | Q9NZT1,Q5SQI3, Q8IXU8, |
| UniProt Related Accession: | Q9NZT1 |
| Molecular Weight: | 15,893 Da |
| NCBI Full Name: | Calmodulin-like protein 5 |
| NCBI Synonym Full Names: | calmodulin like 5 |
| NCBI Official Symbol: | CALML5�� |
| NCBI Official Synonym Symbols: | CLSP�� |
| NCBI Protein Information: | calmodulin-like protein 5 |
| UniProt Protein Name: | Calmodulin-like protein 5 |
| UniProt Synonym Protein Names: | Calmodulin-like skin protein |
| UniProt Gene Name: | CALML5�� |
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