Human CALB2 Recombinant Protein (RPPB2962)
- SKU:
- RPPB2962
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P22676
Description
| Product Name: | Human CALB2 Recombinant Protein |
| Product Code: | RPPB2962 |
| Size: | 25µg |
| Species: | Human |
| Target: | CALB2 |
| Synonyms: | Calretinin, CR, CALB2, CAB29, CAL2, CaBP29K, 29 kDa calbindin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CALB2 1mg/ml protein solution contains 20mM Tris-HCl buffer pH-8 & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSST EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M |
Calretinin is an intracellular calcium-binding protein belonging to the troponin C superfamily characterized by a structural motif described as the EF-hand domain. The immunohistochemical detection of calretinin in developing cerebellum is restricted to the later stages indicated by weak staining from week 21 of gestation, in Purkinje and basket cells and in neurons of the dentate nucleus. The intensity of staining increases as the cerebellum matures. In tumors, calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas.
CALB2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 291 amino acids (1-271 a.a.) and having a molecular mass of 33.7kDa.The CALB2 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CALB2: Calretinin is a calcium-binding protein which is abundant in auditory neurons. Belongs to the calbindin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 16q22.2 Cellular Component: cytoplasm; gap junction; nucleus Molecular Function:calcium ion binding Biological Process: cytosolic calcium ion homeostasis |
| NCBI Summary: | This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P22676 |
| NCBI GenInfo Identifier: | 109940061 |
| NCBI Gene ID: | 794 |
| NCBI Accession: | P22676.2 |
| UniProt Secondary Accession: | P22676,Q53HD2, Q96BK4, A8K4Y1, |
| UniProt Related Accession: | P22676 |
| Molecular Weight: | 31,540 Da |
| NCBI Full Name: | Calretinin |
| NCBI Synonym Full Names: | calbindin 2 |
| NCBI Official Symbol: | CALB2�� |
| NCBI Official Synonym Symbols: | CR; CAL2; CAB29�� |
| NCBI Protein Information: | calretinin; calbindin D29K; 29 kDa calbindin; calbindin 2, (29kD, calretinin) |
| UniProt Protein Name: | Calretinin |
| UniProt Synonym Protein Names: | 29 kDa calbindin |
| UniProt Gene Name: | CALB2�� |
| UniProt Entry Name: | CALB2_HUMAN |
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