Human CALB1 Recombinant Protein (RPPB5864)
- SKU:
- RPPB5864
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P05937
Description
| Product Name: | Human CALB1 Recombinant Protein |
| Product Code: | RPPB5864 |
| Size: | 50µg |
| Species: | Human |
| Target: | CALB1 |
| Synonyms: | Calbindin, Vitamin D-dependent calcium-binding protein, avian-type, Calbindin D28, D-28K, CALB1, CAB27, CALB, calbindin 1 28kDa. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CALB1 protein solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 10% glycerol and 2mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT DLALILCAGD N |
Calbindin 1 (CALB1) is a calcium binding protein that is a member of the troponin C superfamily. CALB1 plays a vital role in calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium associated signaling in neurons and transiently in embryological development. CALB1 also has a role in protecting neurons from apoptotic cell death. CALB1 buffers cytosolic calcium and may stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. The biological function of CALB1 seems to be tied to the redox state of its five cysteine residues.CALB1 has 4 active calcium-binding domains, and 2 modified domains that seemingly have lost their calcium-binding ability. CALB1 is expressed in neural tissues. In the brain, the CALB1 synthesis is independent of vitamin-D-derived hormones. Disregulation of the CALB1 is associated with epilepsy, amyotrophic lateral sclerosis, Huntington's disease. The neurons in brains of Huntington disease patients are calbindin-depleted.
CALB1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 261 amino acids (1-261 a.a.) and having a molecular mass of 30kDa.The CALB1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CALB1: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Interacts with RANBP9. Belongs to the calbindin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 8q21.3 Cellular Component: cell soma; axon; dendrite; synapse; nucleus; cytosol Molecular Function:vitamin D binding; protein binding; zinc ion binding; calcium ion binding Biological Process: cytosolic calcium ion homeostasis; long-term memory; short-term memory; regulation of synaptic plasticity; locomotory behavior |
| NCBI Summary: | Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05937 |
| NCBI GenInfo Identifier: | 115394 |
| NCBI Gene ID: | 793 |
| NCBI Accession: | P05937.2 |
| UniProt Secondary Accession: | P05937,B2R696, B7Z9J4, |
| UniProt Related Accession: | P05937 |
| Molecular Weight: | 23,609 Da |
| NCBI Full Name: | Calbindin |
| NCBI Synonym Full Names: | calbindin 1, 28kDa |
| NCBI Official Symbol: | CALB1�� |
| NCBI Official Synonym Symbols: | CALB�� |
| NCBI Protein Information: | calbindin; D-28K; calbindin D28; RTVL-H protein; calbindin 1, (28kD); vitamin D-dependent calcium-binding protein, avian-type |
| UniProt Protein Name: | Calbindin |
| UniProt Synonym Protein Names: | Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type |
| Protein Family: | Calbindin |
| UniProt Gene Name: | CALB1�� |
| UniProt Entry Name: | CALB1_HUMAN |
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