Enzymes Recombinant Proteins

Human CA14 Recombinant Protein (RPPB1466)

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SKU:
RPPB1466
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9ULX7
Research Area:
Enzymes

Description

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Product Name:Human CA14 Recombinant Protein
Product Code:RPPB1466
Size:20µg
Species:Human
Target:CA14
Synonyms:Carbonic anhydrase 14, Carbonate dehydratase XIV, Carbonic anhydrase XIV, CA-XIV, CA14, CAXiV.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CA14 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:NPL Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSADGGQHW TYEGPHGQDH WPASYPECGN NAQSPIDIQT DSVTFDPDLP ALQPHGYDQP GTEPLDLHNN GHTVQLSLPS TLYLGGLPRK YVAAQLHLHW GQKGSPGGSE HQINSEATFA ELHIVHYDSD SYDSLSEAAE RPQGLAVLGI LIEVGETKNI AYEHILSHLH EVRHKDQKTS VPPFNLRELL PKQLGQYFRY NGSLTTPPCY QSVLWTVFYR RSQISMEQLE KLQGTLFSTE EEPSKLLVQN YRALQPLNQR MVFASFIQAG SSYTTGEM

CA14 is a part of the Carbonic anhydrases family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. They present wide variety in tissue distribution and in their subcellular localization. CA14 is a type I membrane protein which shares highest sequence similarity with the other transmembrane CA isoform, CA XII. Nevertheless, they have different patterns of tissue-specific expression and therefore take different physiologic parts.

CA14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids (16-290 a.a.) and having a molecular mass of 33.2kDa. CA14 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CA14: Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family.
UniProt Protein Details:

Protein type:Energy Metabolism - nitrogen; Membrane protein, integral; Lyase; EC 4.2.1.1

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: integral to membrane; plasma membrane

Molecular Function:carbonate dehydratase activity; metal ion binding

Biological Process: bicarbonate transport

NCBI Summary:Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
UniProt Code:Q9ULX7
NCBI GenInfo Identifier:8928036
NCBI Gene ID:23632
NCBI Accession:Q9ULX7.1
UniProt Secondary Accession:Q9ULX7,Q5TB24, Q8NCF4,
UniProt Related Accession:Q9ULX7
Molecular Weight:337
NCBI Full Name:Carbonic anhydrase 14
NCBI Synonym Full Names:carbonic anhydrase XIV
NCBI Official Symbol:CA14��
NCBI Official Synonym Symbols:CAXiV��
NCBI Protein Information:carbonic anhydrase 14; CA-XIV; carbonic dehydratase; carbonate dehydratase XIV
UniProt Protein Name:Carbonic anhydrase 14
UniProt Synonym Protein Names:Carbonate dehydratase XIV; Carbonic anhydrase XIV; CA-XIV
Protein Family:Carbonic anhydrase
UniProt Gene Name:CA14��
UniProt Entry Name:CAH14_HUMAN
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