Human C8G Recombinant Protein (RPPB2953)

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SKU:
RPPB2953
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P07360

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human C8G Recombinant Protein
Product Code:RPPB2953
Size:20µg
Species:Human
Target:C8G
Synonyms:Complement component 8 gamma polypeptide, C8C, complement component C8 gamma chain, MGC142186.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The C8G solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MQKPQRPRRP ASPISTIQPK ANFDAQQFAG TWLLVAVGSA CRFLQEQGHR AEATTLHVAP QGTAMAVSTF RKLDGICWQV RQLYGDTGVL GRFLLQARGA RGAVHVVVAE TDYQSFAVLY LERAGQLSVK LYARSLPVSD SVLSGFEQRV QEAHLTEDQI FYFPKYGFCE AADQFHVLDE VRR

C8, a component of the complement system consists of three polypeptides C8A, C8B and C8G and takes part in the formation of Membrane Attack Complex (MAC). Patients with C8 deficiency are exposed to several bacteria infections. C8G, a member of the lipocalin family and calycin superfamily, is a secreted protein that can bind retinol. C8G is created in the liver, monocytes and fibroblast and has a role in clearing pathogens from an infected host.

C8G Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (21-202) and having a molecular mass of 22.6 kDa.The C8G is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:C8G: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Belongs to the calycin superfamily. Lipocalin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: membrane attack complex; extracellular region

Molecular Function:complement binding; protein complex binding; retinol binding

Biological Process: cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway

NCBI Summary:The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
UniProt Code:P07360
NCBI GenInfo Identifier:166197660
NCBI Gene ID:733
NCBI Accession:NP_000597.2
UniProt Secondary Accession:P07360,Q14CT8, Q14CU0, Q5SQ07,
UniProt Related Accession:P07360
Molecular Weight:22,277 Da
NCBI Full Name:complement component C8 gamma chain
NCBI Synonym Full Names:complement component 8, gamma polypeptide
NCBI Official Symbol:C8G��
NCBI Official Synonym Symbols:C8C��
NCBI Protein Information:complement component C8 gamma chain
UniProt Protein Name:Complement component C8 gamma chain
Protein Family:Complement component
UniProt Gene Name:C8G��
UniProt Entry Name:CO8G_HUMAN
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system_update_altDatasheetHuman C8G Recombinant Protein Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists