Human C5AR1 Full-Length Bioactive Membrane Protein (HDFP067)

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SKU:
HDFP067
Product Type:
Recombinant Protein
Protein Type:
Full-Length Bioactive Membrane Protein
Species:
Human
Uniprot:
P21730

Description

system_update_altDatasheet
Product nameHuman C5AR1 full length protein-synthetic nanodisc
Size:10ug
Product SKU:HDFP067
Product CategoryFull Length Transmembrane Proteins
Target:C5AR1
Uniprot:P21730
Description:Human C5AR1 full length protein-synthetic nanodisc
Molecular Weight:The human full length C5AR1 protein has a MW of 39.3 kDa
Protein Family:Druggable Genome, GPCR, Transmembrane
Protein Pathways:Complement and coagulation cascades, Neuroactive ligand-receptor interaction
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Synonyms:C5A; C5AR; C5R1; CD88
Expression System:HEK293
Formulation:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Background:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).[UniProtKB/Swiss-Prot Function]
Delivery:3-4 weeks
UsageResearch use only
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