Human C1QTNF5 Recombinant Protein (RPPB2943)

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RPPB2943

Description

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Product Name:Human C1QTNF5 Recombinant Protein
Product Code:RPPB2943
Size:10µg
Species:Human
Target:C1QTNF5
Synonyms:CTRP5, MFRP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The C1QTNF5 protein solution (0.25 mg/ml) is formulated in 20mM Tris-HCl buffer (pH8.5) containing 30% glycerol�and 0.2M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSPPLD DNKIPSLCPG HPGLPGTPGH HGSQGLPGRDGRDGRDGAPG APGEKGEGGR PGLPGPRGDP GPRGEAGPAG PTGPAGECSV PPRSAFSAKRSESRVPPPSD APLPFDRVLV NEQGHYDAVT GKFTCQVPGV YYFAVHATVY RASLQFDLVKNGESIASFFQ FFGGWPKPAS LSGGAMVRLE PEDQVWVQVG VGDYIGIYAS IKTDSTFSGF LVYSDWHSSP VFA

Complement C1q Tumor Necrosis Factor-Related Protein 5 (C1QTNF5) encodes a short-chain collagen which is expressed mainly in sub-retinal pigment epithelium, ciliary epithelium and adipose tissue.�C1QTNF5 is increased in mtDNA-depleted myocytes and stimulates the phosphorylation of AMP activated protein kinase. C1QTNF5 takespart in the adhesion of the retinal pigment epithelium (RPE) to the Bruch Membrane. Mutations in C1QTNF5 have been associated with late-onset retinal degeneration.

C1QTNF5 Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 253 amino acids (16-243.a.a) and having a molecular mass of 26.4kDa. C1QTNF5 Human is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Subunit structure: May interact with FAM132B
UniProt Protein Details:

By similarity. Homotrimer (via collagen-like domain). May form higher order oligomers by supercoiling of the trimers. Ref.10

Subcellular location: Secreted

Probable.

Involvement in Disease: Late-onset retinal degeneration (LORD) [MIM:605670]: Autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11

Miscellaneous: This protein is produced by a bicistronic gene which also produces the MFRP protein from a non-overlapping reading frame.

Sequence similarities: Contains 1 C1q domain.Contains 1 collagen-like domain.

NCBI Summary:This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013]
UniProt Code:Q9BXJ0
NCBI GenInfo Identifier:20177861
NCBI Gene ID:114902
NCBI Accession:Q9BXJ0.1
UniProt Secondary Accession:Q9BXJ0,Q335M2, Q8N6P2, Q9UFX4, A6NDD3, B0YJ35,
UniProt Related Accession:Q9BXJ0
Molecular Weight:25,298 Da
NCBI Full Name:Complement C1q tumor necrosis factor-related protein 5
NCBI Synonym Full Names:C1q and tumor necrosis factor related protein 5
NCBI Official Symbol:C1QTNF5��
NCBI Official Synonym Symbols:CTRP5��
NCBI Protein Information:complement C1q tumor necrosis factor-related protein 5; myonectin; C1q TNF-alpha-related protein 5
UniProt Protein Name:Complement C1q tumor necrosis factor-related protein 5
UniProt Gene Name:C1QTNF5��
UniProt Entry Name:C1QT5_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BXJ0
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