Human C1QTNF3 Recombinant Protein (RPPB2941)
- SKU:
- RPPB2941
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BXJ4
Description
| Product Name: | Human C1QTNF3 Recombinant Protein |
| Product Code: | RPPB2941 |
| Size: | 10µg |
| Species: | Human |
| Target: | C1QTNF3 |
| Synonyms: | Complement C1q tumor necrosis factor-related protein 3, Secretory protein CORS26, C1QTNF3, CTRP3, Cors, Corcs, CORS26, FLJ37576, Cartducin. |
| Source: | Escherichia Coli |
| Formulation: | Human C1QTNF3 was filtered (0.4�m) and lyophilized in 0.5 mg/ml in 0.05M Acetate buffer pH4. |
| Solubility: | It is recommended to add 0.1M Acetate buffer pH4 to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10�g/ml. In higher concentrations the solubility of the protein is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized C1QTNF3 at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted C1QTNF3 can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | The purity of C1QTNF3 is greater than 95% as determined by SDS PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS QDEYMESPQT GGLPPDCSKC CHGDYSFRGY QGPPGPPGPP GIPGNHGNNG NNGATGHEGA KGEKGDKGDL GPRGERGQHG PKGEKGYPGI PPELQIAFMA SLATHFSNQN SGIIFSSVET NIGNFFDVMT GRFGAPVSGV YFFTFSMMKH EDVEEVYVYL MHNGNTVFSM YSYEMKGKSD TSSNHAVLKL AKGDEVWLRM GNGALHGDHQ RFSTFAGFLLFETK |
C1QTNF3 also called Cartducin is a novel angiogenic factor in the formation of neointima following angioplasty. C1QTNF3 a paralog of Acrp30 (adiponectin). C1QTNF3 is a secretory protein produced by chondrogenic precursors & proliferating chondrocytes, and belongs to a novel C1q family of proteins. Cartducin promotes the growth of mesenchymal chondroprogenitor cells & chondrosarcoma-derived chondrocytic cells in vitro. Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways. C1QTNF3 promotes proliferation & the migration of endothelial cells.
C1QTNF3 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 234 amino acids and having a molecular mass of 25.4 kDa. The protein contains an extra 10 aa His tag at N-terminus. The C1QTNF3 amino acid sequence is identical to UniProtKB/Swiss-Prot entry Q9BXJ4 amino acids 23�246. The C1QTNF3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | C1QTNF3: 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 5p13 Cellular Component: extracellular space; collagen; membrane Molecular Function:protein binding Biological Process: fat cell differentiation; negative regulation of gluconeogenesis; negative regulation of inflammatory response; negative regulation of NF-kappaB import into nucleus; positive regulation of cytokine secretion |
| UniProt Code: | Q9BXJ4 |
| NCBI GenInfo Identifier: | 20177865 |
| NCBI Gene ID: | 114899 |
| NCBI Accession: | Q9BXJ4.1 |
| UniProt Secondary Accession: | Q9BXJ4,Q0VAN4, Q542Y2, Q6MZN1, Q96KY1, |
| UniProt Related Accession: | Q9BXJ4 |
| Molecular Weight: | 35,183 Da |
| NCBI Full Name: | Complement C1q tumor necrosis factor-related protein 3 |
| NCBI Synonym Full Names: | C1q and tumor necrosis factor related protein 3 |
| NCBI Official Symbol: | C1QTNF3�� |
| NCBI Official Synonym Symbols: | CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26�� |
| NCBI Protein Information: | complement C1q tumor necrosis factor-related protein 3; cartonectin; collagenous repeat-containing sequence 26 kDa protein; collagenous repeat-containing sequence of 26-kDa; secretory protein CORS26 |
| UniProt Protein Name: | Complement C1q tumor necrosis factor-related protein 3 |
| UniProt Synonym Protein Names: | Collagenous repeat-containing sequence 26 kDa protein; CORS26; Secretory protein CORS26 |
| Protein Family: | Complement C1q tumor necrosis factor-related protein |
| UniProt Gene Name: | C1QTNF3�� |
| UniProt Entry Name: | C1QT3_HUMAN |
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