Human BTN3A1 Recombinant Protein (RPPB2916)

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SKU:
RPPB2916
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O00481

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human BTN3A1 Recombinant Protein
Product Code:RPPB2916
Size:5µg
Species:Human
Target:BTN3A1
Synonyms:Butyrophilin Subfamily 3 Member A1, BTF5, DJ45P21.3 (Butyrophilin, Subfamily 3, Member A1), Butyrophilin, Subfamily 3, Member A1, CD277 Antigen, BTN3.1, BT3.1, CD277, Butyrophilin subfamily 3 member A1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:BTN3A1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:QFSVLGPSGP ILAMVGEDAD LPCHLFPTMS AETMELKWVS SSLRQVVNVY ADGKEVEDRQ SAPYRGRTSI LRDGITAGKA ALRIHNVTAS DSGKYLCYFQ DGDFYEKALV ELKVAALGSD LHVDVKGYKD GGIHLECRST GWYPQPQIQW SNNKGENIPT VEAPVVADGV GLYAVAASVI MRGSSGEGVS CTIRSSLLGL EKTASISIAD PFFRSAQRWI AALAGLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY�TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH

Butyrophilin sub family 3 member A1, also known as BTN3A1 is a member of the immunoglobulin superfamily. BTN3A1 is composed of an extracellular N-terminal IgV as well as a membrane proximal IgC domain followed by a transmembrane domain and also a cytoplasmic tail. BTN3A1 participates in T-cell activation and also in the adaptive immune response. Furthermore, BTN3A1 regulates the proliferation of activated T-cells & the release of cytokines and IFNG by activated T-cells. BTN3A1, Mediates the response of T-cells to infected as well as transformed cells which are categorized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

BTN3A1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 464 amino acids (30-254a.a.) and having a molecular mass of 51.1kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).BTN3A1 is expressed with a 239 amino acid hIgG-His Tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
NCBI Summary:The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
UniProt Code:O00481
NCBI GenInfo Identifier:117949374
NCBI Gene ID:11119
NCBI Accession:O00481.3
UniProt Secondary Accession:O00481,Q0P515, Q147X5, Q53F15, Q99420, Q9HCY1, A2A278 A8K2C8, B4DIQ1, B4DRM2, E9PGB4, E9PHG8,
UniProt Related Accession:O00481
Molecular Weight:52,019 Da
NCBI Full Name:Butyrophilin subfamily 3 member A1
NCBI Synonym Full Names:butyrophilin subfamily 3 member A1
NCBI Official Symbol:BTN3A1��
NCBI Official Synonym Symbols:BTF5; BT3.1; CD277; BTN3.1��
NCBI Protein Information:butyrophilin subfamily 3 member A1
UniProt Protein Name:Butyrophilin subfamily 3 member A1
UniProt Synonym Protein Names:CD_antigen: CD277
UniProt Gene Name:BTN3A1��
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