Description
| Product Name: | Human BTC His Recombinant Protein |
| Product Code: | RPPB0120 |
| Size: | 10µg |
| Species: | Human |
| Target: | BTC His |
| Synonyms: | Betacellulin, Probetacellulin.� |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The BTC solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 0.2M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDGNSTRSPE TNGLLCGDPE ENCAATTTQS KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF Y |
Btc is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the egf receptor and other related receptors.
BTC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (32-111) and having a molecular mass of 11.3 kDa.BTC is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Cell cycle regulation; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: extracellular space; plasma membrane; integral to membrane; extracellular region Molecular Function:protein binding; growth factor activity; epidermal growth factor receptor binding Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of cell proliferation; innate immune response; positive regulation of cell differentiation; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35070 |
| NCBI GenInfo Identifier: | 461653 |
| NCBI Gene ID: | 685 |
| NCBI Accession: | P35070.1 |
| UniProt Secondary Accession: | P35070,Q96F48, |
| UniProt Related Accession: | P35070 |
| Molecular Weight: | 19,746 Da |
| NCBI Full Name: | Probetacellulin |
| NCBI Synonym Full Names: | betacellulin |
| NCBI Official Symbol: | BTC�� |
| NCBI Protein Information: | probetacellulin |
| UniProt Protein Name: | Probetacellulin |
| Protein Family: | Probetacellulin |
| UniProt Gene Name: | BTC�� |
| UniProt Entry Name: | BTC_HUMAN |
