Human BRD3 Recombinant Protein (RPPB2908)

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SKU:
RPPB2908
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15059

Description

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Product Name:Human BRD3 Recombinant Protein
Product Code:RPPB2908
Size:20µg
Species:Human
Target:BRD3
Synonyms:ORFX, RING3L, Bromodomain-containing protein 3, RING3-likeprotein, KIAA0043, RING3L.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:BRD3 protein solution (0.5mg/ml) containing PBS buffer(pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSTATTV APAGIPATPG PVNPPPPEVS NPSKPGRKTN QLQYMQNVVVKTLWKHQFAW PFYQPVDAIK LNLPDYHKII KNPMDMGTIK KRLENNYYWS ASECMQDFNT MFTNCYIYNKPTDDIVLMAQ ALEKIFLQKV AQMPQEEVEL LPPAPKGKGR KPAAGAQSAG TQQVAAVSSV SPATPFQSVPPTVSQTPVIA ATPVPTITAN VTSVPVPPAA APPPPATPIV PVVPPTPPVV KKKGVKRKAD TTTPTTSAITASRSESPPPL SDPKQAKVVA RRESGGRPIK PPKKDLEDGE VPQHAGKKGK LSEHLRYCDS ILREMLSKKHAAYAWPFYKP VDAEALELHD YHDIIKHPMD LSTVKRKMDG REYPDAQGFA ADVRLMFSNC YKYNPPDHEVVAMARKLQDV FEMRFAKMP

Bromodomain Containing 3 (BRD3) was classified based on its homology to the gene encoding the RING3 protein, which is a serine/threonine kinase. The BRD3 protein localizes to 9q34, a region which contains a number of major histocompatibility complex (MHC) genes. The function of the BRD3 protein is unknown.

BRD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 439 amino acids (1-416 a.a) and having a molecular mass of 48.1kDa.BRD3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:BRD3: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. Regulates transcription of the CCND1 gene. A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, atypical; ATYPICAL group; BRD family

Chromosomal Location of Human Ortholog: 9q34

Molecular Function:chromatin binding; protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
UniProt Code:Q15059
NCBI GenInfo Identifier:12643726
NCBI Gene ID:8019
NCBI Accession:Q15059.1
UniProt Secondary Accession:Q15059,Q4G5Y3, Q5T1R7, Q8N5M3, Q92645, B1APD9,
UniProt Related Accession:Q15059
Molecular Weight:60,942 Da
NCBI Full Name:Bromodomain-containing protein 3
NCBI Synonym Full Names:bromodomain containing 3
NCBI Official Symbol:BRD3��
NCBI Official Synonym Symbols:ORFX; RING3L��
NCBI Protein Information:bromodomain-containing protein 3
UniProt Protein Name:Bromodomain-containing protein 3
UniProt Synonym Protein Names:RING3-like protein
Protein Family:Bromodomain-containing protein
UniProt Gene Name:BRD3��
UniProt Entry Name:BRD3_HUMAN
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