Human BRD2 Recombinant Protein (RPPB2907)

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SKU:
RPPB2907
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P25440

Description

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Product Name:Human BRD2 Recombinant Protein
Product Code:RPPB2907
Size:20µg
Species:Human
Target:BRD2
Synonyms:Bromodomain Containing 2, RING3, Really Interesting NewGene 3 Protein, Bromodomain-Containing 2, O27.1.1, FSRG1, Female Sterile Homeotic-RelatedGene 1, Bromodomain-Containing Protein 2, KIAA9001, D6S113E, RNF3, FSH, NAT,Bromodomain-containing protein 2 .
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:BRD2 protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMLQNVTP HNKLPGEGNA GLLGLGPEAA APGKRIRKPS LLYEGFESPTMASVPALQLT PANPPPPEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKIIKQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNKPTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQGSVTSAHQVPA VSSVSHTALY TPPPEIPTTV LNIPHPSVIS SPLLKSLHSA GPPLLAVTAA PPAQPLAKKKGVKRKADTTT PTPTAILAPG SPASPPGSLE PKAARLPPMR RESGRPIKPP RKDLPDSQQQHQSSKKGKLS EQLKHCNGIL KELLSKKHAA YAWPFYKPVD ASALGLHDYHDIIKHPMDLS TVKRKMENRD YRDAQEFAAD VRLMFSNCYK YNPPDHDVVA MARKLQDVFE FRYAKMPD

Bromodomain Containing 2, also known as BRD2 is a transcriptionalregulator which is a member of the BET, bromodomains and extra terminal domain, family ofroteins. BRD2 links with transcription complexes and it acetylated chromatin inthe course of mitosis, and it selectively binds o the acetylated lysine-12 residue ofhistone H4 through its two romodomains. BRD2 maps to the majorhistocompatability complex� MHC) class IIregion on chromosome 6p21.3, however sequence comparison�advocate that the protein is not implicated in the immune response. BRD2has been implicated in juvenilemyoclonic epilepsy, a common form of epilepsy which grows to be visible inadolescence.

BRD2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 478 amino acids (1-455 a.a) andhaving a molecular mass of 52.8kDa.BRD2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
NCBI Summary:This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:P25440
NCBI GenInfo Identifier:12230989
NCBI Gene ID:6046
NCBI Accession:P25440.2
UniProt Secondary Accession:P25440,O00699, O00700, Q15310, Q5STC9, Q63HQ9, Q658Y7 Q6P3U2, Q969U4, A2AAU0, B0S7P0, B1AZT1,
UniProt Related Accession:P25440
Molecular Weight:74,881 Da
NCBI Full Name:Bromodomain-containing protein 2
NCBI Synonym Full Names:bromodomain containing 2
NCBI Official Symbol:BRD2��
NCBI Official Synonym Symbols:FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1��
NCBI Protein Information:bromodomain-containing protein 2
UniProt Protein Name:Bromodomain-containing protein 2
UniProt Synonym Protein Names:O27.1.1; Really interesting new gene 3 protein
Protein Family:Bromodomain-containing protein
UniProt Gene Name:BRD2��
UniProt Entry Name:BRD2_HUMAN
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