Human BRD1 Recombinant Protein (RPPB2906)
- SKU:
- RPPB2906
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95696
Description
| Product Name: | Human BRD1 Recombinant Protein |
| Product Code: | RPPB2906 |
| Size: | 20µg |
| Species: | Human |
| Target: | BRD1 |
| Synonyms: | Bromodomain Containing 1, BRL, Bromodomain And PHD Finger-Containing Protein2, BR140-Like Protein, BRPF2, Bromodomain-Containing Protein 1, Bromodomain-Containing 1, BR140-Like, BRPF1, BRD1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | BRD1 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEQVAMEL RLTPLTVLLR SVLDQLQDKD PARIFAQPVS LKEVPDYLDH IKHPMDFATM RKRLEAQGYK NLHEFEEDFD LIIDNCMKYN ARDTVFYRAA VRLRDQGGVV LRQARREVDS IGLEEASGMH LPERPA |
Bromodomain Containing 1 also known as BRD1 contains a bromodomain,which is a sequence motif frequently found in transcriptional coactivators, andlocalizes to the nucleus in testis and several other cell types. Variations in BRD1are connected with schozophrenia & bipolar disorder.
BRD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (556-688 a.a) and having a molecular mass of 17.8kDa.BRD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BRD1: a nuclear protein containing a bromo-domain, a PHD domain, and a PWWP domain. Encoded by a susceptibility gene for schizophrenia and bipolar affective disorder. May play a role in neurodevelopment. |
| UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: nucleoplasm; nucleus Molecular Function:histone binding |
| NCBI Summary: | This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| UniProt Code: | O95696 |
| NCBI GenInfo Identifier: | 12229697 |
| NCBI Gene ID: | 23774 |
| NCBI Accession: | O95696.1 |
| UniProt Secondary Accession: | O95696,A6ZJA4, |
| UniProt Related Accession: | O95696 |
| Molecular Weight: | 133,243 Da |
| NCBI Full Name: | Bromodomain-containing protein 1 |
| NCBI Synonym Full Names: | bromodomain containing 1 |
| NCBI Official Symbol: | BRD1�� |
| NCBI Official Synonym Symbols: | BRL; BRPF1; BRPF2�� |
| NCBI Protein Information: | bromodomain-containing protein 1 |
| UniProt Protein Name: | Bromodomain-containing protein 1 |
| UniProt Synonym Protein Names: | BR140-like protein; Bromodomain and PHD finger-containing protein 2 |
| UniProt Gene Name: | BRD1�� |
| UniProt Entry Name: | BRD1_HUMAN |
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