Human BPIFA1 Recombinant Protein (RPPB2905)

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SKU:
RPPB2905
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NP55

Description

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Product Name:Human BPIFA1 Recombinant Protein
Product Code:RPPB2905
Size:20µg
Species:Human
Target:BPIFA1
Synonyms:BPI fold-containing family A member 1, Lung-specific protein X, Nasopharyngeal carcinoma-related protein, Palate lung and nasal epithelium clone protein, Secretory protein in upper respiratory tracts, Tracheal epithelium-enriched protein, Von Ebner protein Hl, BPIFA1, LUNX, NASG, PLUNC, SPURT, SPLUNC1, bA49G10.5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:BPIFA1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQFGGLPV PLDQTLPLNV NPALPLSPTG LAGSLTNALS NGLLSGGLLG ILENLPLLDI LKPGGGTSGG LLGGLLGKVT SVIPGLNNII DIKVTDPQLL ELGLVQSPDG HRLYVTIPLG IKLQVNTPLV GASLLRLAVK LDITAEILAV RDKQERIHLV LGDCTHSPGS LQISLLDGLG PLPIQGLLDS LTGILNKVLP ELVQGNVCPL VNEVLRGLDI TLVHDIVNML IHGLQFVIKV

BPI fold containing family A Member 1 (BPIFA1) belongs to the short subfamily of PLUNC family proteins and have homology only to the Nterminal domains of BPI. BPIFA1 is a secreted protein which is expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. BPIFA1 binds to LPS (lipopolysaccharide) in nasal lavage fluid (NLF) which alludes to its role in the inflammatory response of the upper airways after exposure to irritants. BPIFA1 may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Decreased levels of BPIFA1 are observed in the NLF of smokers and people who have been exposed to reactive epoxy chemicals, which indicats that long-term exposure to airway irritants damages the production of BPIFA1 in the upper respiratory tract.

BPIFA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 260 amino acids (20-256 a.a) and having a molecular mass of 27.1kDa.BPIFA1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NCBI Summary:This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]
UniProt Code:Q9NP55
NCBI GenInfo Identifier:342307069
NCBI Gene ID:51297
NCBI Accession:NP_001230122.1
UniProt Related Accession:Q9NP55
Molecular Weight:
NCBI Full Name:BPI fold-containing family A member 1
NCBI Synonym Full Names:BPI fold containing family A member 1
NCBI Official Symbol:BPIFA1��
NCBI Official Synonym Symbols:LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5��
NCBI Protein Information:BPI fold-containing family A member 1
UniProt Protein Name:BPI fold-containing family A member 1
UniProt Synonym Protein Names:Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl
UniProt Gene Name:BPIFA1��
UniProt Entry Name:BPIA1_HUMAN
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