Human BNIP1 Recombinant Protein (RPPB2901)
- SKU:
- RPPB2901
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q12981
Description
| Product Name: | Human BNIP1 Recombinant Protein |
| Product Code: | RPPB2901 |
| Size: | 20µg |
| Species: | Human |
| Target: | BNIP1 |
| Synonyms: | BCL2/Adenovirus E1B 19kDa Interacting Protein 1, NIP1, BCL2/AdenovirusE1B 19 KDa Protein-Interacting Protein 1, Transformation-Related Gene 8Protein, TRG-8, BCL2/Adenovirus E1B 19kD-Interacting Protein 1, VesicleTransport Protein SEC20, SEC20L, SEC20, Vesicle transport protein SEC20. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | BNIP1protein solution (1.0 mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAAPQDV HVRICNQEIV KFDLEVKALI QDIRDCSGPL SALTELNTKVKEKFQQLRHR IQDLEQLAKE QDKESEKQLL LQEVENHKKQ MLSNQASWRK ANLTCKIAID NLEKAELLQGGDLLRQRKTT KESLAQTSST ITESLMGISR MMAQQVQQSEEAMQSLVTSS RTILDANEEF KSMSGTIQLG RKLITKYNRR EL |
BNIP1 belongs to the of the BCL2/adenovirus E1B 19 kd-interactingprotein (BNIP) family. BNIP1 interacts with the E1B 19 kDa protein, which defendscells from virally-induced cell death. In addition, BNIP1 interacts with E1B 19kDa-like sequences of BCL2 which is an additional apoptotic protector. Addingup, BNIP1 is implicated in vesicle transport into the endoplasmic reticulum.Alternative splicing results of BNIP1 in four protein products with identicalN- and C-termini have been found.
BNIP1 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 222 amino acids (1-199 a.a) and having a molecularmass of 25.2kDa.BNIP1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BNIP1: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy. Belongs to the SEC20 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 5q33-q34 Cellular Component: SNARE complex; mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; integral to endoplasmic reticulum membrane; nuclear envelope Molecular Function:SNAP receptor activity; protein binding Biological Process: endoplasmic reticulum organization and biogenesis; endoplasmic reticulum membrane fusion; vesicle-mediated transport; apoptosis; autophagy; negative regulation of apoptosis |
| NCBI Summary: | This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q12981 |
| NCBI GenInfo Identifier: | 93141310 |
| NCBI Gene ID: | 662 |
| NCBI Accession: | Q12981.3 |
| UniProt Secondary Accession: | Q12981,O75622, O75623, O75624, Q6K044, Q96FG4, D3DQM3 D3DQM4, D3DQM5, D3DQM6, |
| UniProt Related Accession: | Q12981 |
| Molecular Weight: | 228 |
| NCBI Full Name: | Vesicle transport protein SEC20 |
| NCBI Synonym Full Names: | BCL2/adenovirus E1B 19kDa interacting protein 1 |
| NCBI Official Symbol: | BNIP1�� |
| NCBI Official Synonym Symbols: | NIP1; SEC20; TRG-8�� |
| NCBI Protein Information: | vesicle transport protein SEC20; transformation-related gene 8 protein; BCL2/adenovirus E1B 19 kDa protein-interacting protein 1 |
| UniProt Protein Name: | Vesicle transport protein SEC20 |
| UniProt Synonym Protein Names: | BCL2/adenovirus E1B 19 kDa protein-interacting protein 1; Transformation-related gene 8 protein; TRG-8 |
| Protein Family: | Vesicle transport protein |
| UniProt Gene Name: | BNIP1�� |
| UniProt Entry Name: | SEC20_HUMAN |
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