Cytokines Recombinant Proteins

Human BMPR1B Recombinant Protein (RPPB0091)

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SKU:
RPPB0091
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O00238
Research Area:
Cytokines

Description

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Product Name:Human BMPR1B Recombinant Protein
Product Code:RPPB0091
Size:10µg
Species:Human
Target:BMPR1B
Synonyms:Bone Morphogenetic Protein Receptor, Type IB, BMP Type-1B Receptor, EC 2.7.11.30, BMPR-1B, ALK6, Bone Morphogenetic Protein Receptor Type-1B, Serine/Threonine Receptor Kinase, CDw293 Antigen, EC 2.7.11, CDw293, ALK-6, Bone morphogenetic protein receptor type-1B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:BMPR1B protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 20% glycerol, 1mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEEDDSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHR

Bone Morphogenetic protein Receptor-1B, also known as BMPR1B belongs tothe TKL Ser/Thr protein kinase family. BMPR1B is on ligand binding,forms a receptor complex consisting of two type II and two type I transmembraneserine/threonine kinases. Type II receptors phosphorylate as well as activate type Ireceptors which autophosphorylate, afterward bind and activate SMADtranscriptional regulators. BMPR1B isreceptor for BMP7/OP-1 as well as GDF5.

BMPR1B Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 136 amino acids (14-126 a.a) andhaving a molecular mass of 15.1kDa.BMPR1B is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.
UniProt Protein Details:

Protein type:Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22-q24

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function:protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: chondrocyte development; positive regulation of bone mineralization; limb morphogenesis; protein amino acid phosphorylation; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; eye development; dorsal/ventral pattern formation; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; positive regulation of cell differentiation; inflammatory response; skeletal development; retinal ganglion cell axon guidance; cartilage condensation

Disease: Chondrodysplasia, Acromesomelic, With Genital Anomalies; Brachydactyly, Type A2

NCBI Summary:This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:O00238
NCBI GenInfo Identifier:6226778
NCBI Gene ID:658
NCBI Accession:O00238.1
UniProt Secondary Accession:O00238,P78366, B2R953, B4DSV1,
UniProt Related Accession:O00238
Molecular Weight:502
NCBI Full Name:Bone morphogenetic protein receptor type-1B
NCBI Synonym Full Names:bone morphogenetic protein receptor, type IB
NCBI Official Symbol:BMPR1B��
NCBI Official Synonym Symbols:ALK6; ALK-6; CDw293��
NCBI Protein Information:bone morphogenetic protein receptor type-1B; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase
UniProt Protein Name:Bone morphogenetic protein receptor type-1B
UniProt Synonym Protein Names:CD_antigen: CDw293
Protein Family:Bone morphogenetic protein receptor
UniProt Gene Name:BMPR1B��
UniProt Entry Name:BMR1B_HUMAN
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