Growth Factors & Cytokines Recombinant Proteins

Human BMP8B Recombinant Protein (RPPB0106)

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SKU:
RPPB0106
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P34820
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human BMP8B Recombinant Protein
Product Code:RPPB0106
Size:20µg
Species:Human
Target:BMP8B
Synonyms:Bone morphogenetic protein 8B, BMP-8, BMP-8B, Osteogenic protein 2, OP-2, BMP8B, BMP8, Bone Morphogenetic protein-8b, OP2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:BMP8B protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH

Bone Morphogenetic protein-8b (BMP8B) belongs to a family of secreted signaling molecules which can induce ectopic bone growth. BMP8B is known for having a possible bone inductive activity as it is related to BMP5 and BMP7. BMP8B is the osteoinductive factor accountable for epithelial osteogenesis.

BMP8B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 162 amino acids (264-402a.a.) and having a molecular mass of 18.1kDa.BMP8B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:BMP8B: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Belongs to the TGF-beta family.Protein type: Secreted; Secreted, signal peptide; CytokineChromosomal Location of Human Ortholog: 1p35-p32Cellular Component: extracellular spaceMolecular Function: cytokine activity; growth factor activity; transforming growth factor beta receptor bindingBiological Process: BMP signaling pathway; cartilage development; cell development; growth; ossification; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development
UniProt Protein Details:
NCBI Summary:
UniProt Code:P34820
NCBI GenInfo Identifier:7018292
NCBI Gene ID:
NCBI Accession:CAB75681
UniProt Secondary Accession:P34820,Q32NE5, Q53ZM7, Q9NUF0, E7EMY8
UniProt Related Accession:P34820
Molecular Weight:39,151 Da
NCBI Full Name:
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Bone morphogenetic protein 8B
UniProt Synonym Protein Names:Osteogenic protein 2; OP-2
Protein Family:
UniProt Gene Name:BMP8B��
UniProt Entry Name:BMP8B_HUMAN
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