Cytokines Recombinant Proteins

Human BMP 2 Recombinant Protein (RPPB0094)

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SKU:
RPPB0094
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P12643
Research Area:
Cytokines

Description

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Product Name:Human BMP 2 Recombinant Protein
Product Code:RPPB0094
Size:20µg
Species:Human
Target:BMP 2
Synonyms:BMP-2, BMP2A, Bone morphogenetic protein 2, BMP-2A, BMP2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:BMP-2 solution contains 10mM NaAc pH=3.5 and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISMLYLDENEKVV LKNYQDMVVE GCGCR

BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.

Bone Morphogenetic Protein-2 Human Recombinant produced in E.Coli is a monomeric, non-glycosylated, Polypeptide chain containing 115 amino acids (283-396) and having a molecular mass of 13009 Dalton. The BMP-2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
NCBI Summary:The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
UniProt Code:P12643
NCBI GenInfo Identifier:115068
NCBI Gene ID:650
NCBI Accession:P12643.1
UniProt Related Accession:P12643
Molecular Weight:
NCBI Full Name:Bone morphogenetic protein 2
NCBI Synonym Full Names:bone morphogenetic protein 2
NCBI Official Symbol:BMP2��
NCBI Official Synonym Symbols:BDA2; BMP2A��
NCBI Protein Information:bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A
UniProt Protein Name:Bone morphogenetic protein 2
UniProt Synonym Protein Names:Bone morphogenetic protein 2A; BMP-2A
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP2��
UniProt Entry Name:BMP2_HUMAN
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