Cytokines Recombinant Proteins

Human BMP 2 Protein Recombinant Protein (RPPB0092)

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SKU:
RPPB0092
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P12643
Research Area:
Cytokines

Description

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Product Name:Human BMP 2 Protein Recombinant Protein
Product Code:RPPB0092
Size:10µg
Species:Human
Target:BMP 2 Protein
Synonyms:BMP-2, BMP2A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:BMP2 was lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM sodium citrate pH=3.5.
Solubility:It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-2 in sterile 20mM AcOH (acetic Acid) not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Bone Morphogenetic Protein-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Biological Activity:The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 cells is 0.5-1.0 �g/ml.

BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.

Bone Morphogenetic Protein-2 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing 2x115 amino acids and having a molecular mass of 26kDa. The BMP-2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
NCBI Summary:The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
UniProt Code:P12643
NCBI GenInfo Identifier:115068
NCBI Gene ID:650
NCBI Accession:P12643.1
UniProt Related Accession:P12643
Molecular Weight:
NCBI Full Name:Bone morphogenetic protein 2
NCBI Synonym Full Names:bone morphogenetic protein 2
NCBI Official Symbol:BMP2��
NCBI Official Synonym Symbols:BDA2; BMP2A��
NCBI Protein Information:bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A
UniProt Protein Name:Bone morphogenetic protein 2
UniProt Synonym Protein Names:Bone morphogenetic protein 2A; BMP-2A
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP2��
UniProt Entry Name:BMP2_HUMAN
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