Human BIN2 Recombinant Protein (RPPB5856)

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RPPB5856

Description

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Product Name:Human BIN2 Recombinant Protein
Product Code:RPPB5856
Size:5µg
Species:Human
Target:BIN2
Synonyms:Bridging Integrator 2, Breast Cancer-Associated Protein 1, Breast Cancer Associated Protein BRAP1, BRAP-1, BRAP1, BIN2.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:BIN2 protein solution (0.25mg/ml) contains Phosphate buffered saline (pH7.4), 20% glycerol, 1mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPMRGMPGA RTSSSGASEN HRARGQGGGP QGVGRMAEGK AGGAAGLFAK QVQKKFSRAQ EKVLQKLGKA VETKDERFEQ SASNFYQQQA EGHKLYKDLK NFLSAVKVMH ESSKRVSETL QEIYSSEWDG HEELKAIVWN NDLLWEDYEE KLADQAVRTM EIYVAQFSEI KERIAKRGRK LVDYDSARHH LEAVQNAKKK DEAKTAKAEE EFNKAQTVFE DLNQELLEEL PILYNSRIGC YVTIFQNISN LRDVFYREMS KLNHNLYEVM SKLEKQHSNK VFVVKGLSSS SRRSLVISPP VRTATVSSPL TSPTSPSTLS LKSESESVSA TEDLAPDAAQ GEDNSEIKEL LEEEEIEKEG SEASSSEEDE PLPACNGPAQ AQPSPTTERA KSQEEVLPSS TTPSPGGALS PSGQPSSSAT EVVLRTRTAS EGSEQPKKRA SIQRTSAPPS RPPPPRATAS PRPSSGNIPS SPTASGGGSP TSPRASLGTG TASPRTSLEV SPNPEPPEKP VRTPEAKENE NIHNQNPEEL CTSPTLMTSQ VASEPGEAKK MEDKEKDNKL ISANSSEGQD QLQVSMVPEN NNLTAPEPQE EVSTSENPQL HHHHHH

BIN2, also known as Bridging Integrator 2, is a cytoplasmic protein. BIN2 comprises one BAR domain and Interacts with BIN1. BIN2 is highly expressed in some hematopoietic tissues, including peripheral blood, colon, thymus and placenta. BIN2 stimulates cell motility and migration, most likely through its interaction with the cell membrane and with podosome proteins which mediate interaction with the cytoskeleton and likewise modulates membrane curvature & mediates membrane tubulation.

BIN2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (1-597 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 606 amino acids and having a molecular mass of 66.1kDa.BIN2 shows multiple bands between 70-100kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

UniProt Protein Function:Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9UBW5
NCBI GenInfo Identifier:143811367
NCBI Gene ID:51411
NCBI Accession:Q9UBW5.3
UniProt Secondary Accession:Q9UBW5,Q86VV0, Q9NWK4, Q9UKN4
UniProt Related Accession:Q9UBW5
Molecular Weight:58,030 Da
NCBI Full Name:Bridging integrator 2
NCBI Synonym Full Names:bridging integrator 2
NCBI Official Symbol:BIN2��
NCBI Official Synonym Symbols:BRAP-1��
NCBI Protein Information:bridging integrator 2
UniProt Protein Name:Bridging integrator 2
UniProt Synonym Protein Names:Breast cancer-associated protein 1
Protein Family:Bridging integrator
UniProt Gene Name:BIN2��
UniProt Entry Name:
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UBW5
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