Enzymes Recombinant Proteins

Human BHMT Recombinant Protein (RPPB1443)

(No reviews yet) Write a Review
SKU:
RPPB1443
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q93088
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human BHMT Recombinant Protein
Product Code:RPPB1443
Size:50µg
Species:Human
Target:BHMT
Synonyms:BHMT, Betaine Homocysteine S-Methyltransferase 1, BHMT1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear colorless solution 1 mg/ml.
Formulation:The BHMT solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMPP VGGKKAKKGI LERLNAGEIV IGDGGFVFAL EKRGYVKAGP WTPEAAVEHP EAVRQLHREF LRAGSNVMQT FTFYASEDKL ENRGNYVLEK ISGQEVNEAA CDIARQVADE GDALVAGGVS QTPSYLSCKS ETEVKKVFLQ QLEVFMKKNV DFLIAEYFEH VEEAVWAVET LIASGKPVAA TMCIGPEGDL HGVPPGECAV RLVKAGASII GVNCHFDPTI SLKTVKLMKE GLEAARLKAH LMSQPLAYHT PDCNKQGFIDLPEFPFGLEP RVATRWDIQK YAREAYNLGV RYIGGCCGFE PYHIRAIAEE LAPERGFLPPASEKHGSWGS GLDMHTKPWV RARARKEYWE NLRIASGRPY NPSMSKPDGW GVTKGTAELM QQKEATTEQQ LKELFEKQKF KSQ

Betaine-homocysteine methyltransferase (BHMT) is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. BHMT displays differential expression in a model of liver cirrhosis.

Betaine Homocysteine S-Methyltransferase Human Recombinant fused to His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 443 amino acids (21-236) and having a molecular mass of 49.2 kDa. The BHMT is purified by proprietary chromatographic techniques.

UniProt Protein Function:BHMT: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.5; Methyltransferase

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: protein complex; cytoplasm; cytosol

Molecular Function:betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding; protein complex binding

Biological Process: S-methylmethionine cycle; protein amino acid methylation; betaine catabolic process; sulfur amino acid metabolic process; S-adenosylmethionine metabolic process; response to organic nitrogen; regulation of homocysteine metabolic process; betaine metabolic process

NCBI Summary:This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]
UniProt Code:Q93088
NCBI GenInfo Identifier:145559446
NCBI Gene ID:635
NCBI Accession:Q93088.2
UniProt Secondary Accession:Q93088,O09171,
UniProt Related Accession:Q93088
Molecular Weight:45kDa
NCBI Full Name:Betaine--homocysteine S-methyltransferase 1
NCBI Synonym Full Names:betaine--homocysteine S-methyltransferase
NCBI Official Symbol:BHMT��
NCBI Official Synonym Symbols:BHMT1; HEL-S-61p��
NCBI Protein Information:betaine--homocysteine S-methyltransferase 1
UniProt Protein Name:Betaine--homocysteine S-methyltransferase 1
Protein Family:Betaine--homocysteine S-methyltransferase
UniProt Gene Name:BHMT��
UniProt Entry Name:BHMT1_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products